Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-08-22
2006-08-22
Shibuya, Mark (Department: 1639)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007200, C435S007800, C435S007900, C436S501000, C436S518000, C530S387100, C530S388100, C530S388220, C424S187100
Reexamination Certificate
active
07094550
ABSTRACT:
A method for treating or preventing cardiovascular pathologies by administering a compound of the formula (I):wherein Z is C═O or a covalent bond; Y is H or O(C1–C4)alkyl, R1and R2are individually (C1–C4)alkyl or together with N are a saturated heterocyclic group, R3is ethyl or chloroethyl, R4is H or together with R3is —CH2—CH2— or —S—, R5is I, O(C1–C4)alkyl or H, and R6is I, O(C1–C4)alkyl or H with the proviso that when R4, R5, and R6are H, R3is not ethyl; or a pharmaceutically acceptable salt thereof, effective to activate or stimulate production of TGF-beta to treat and/or prevent conditions such as atherosclerosis, thrombosis, myocardial infarction, and stroke is provided. Useful compounds include idoxifene and salts thereof. Further provided is a method for identifying a compound that is a TGF-beta activator or production stimulator is provided. Another embodiment of the invention is an assay or kit to determine TGF-beta in vitro. Also provided is a therapeutic method comprising inhibiting smooth muscle cell proliferation associated with procedural vascular trauma employing the administration of tamoxifen or structural analogs thereof, including compounds of formula (I).
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Grainger David J.
Kemp Paul R.
Baker & Botts LLP
NeoRx Corporation
Shibuya Mark
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