Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Reexamination Certificate
2008-01-25
2009-12-29
Kim, Young J (Department: 1637)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
C435S006120, C435S091100
Reexamination Certificate
active
07638310
ABSTRACT:
A genotyping method and a prepared oligomicroarray as device is to determine single nucleotide polymorphism (SNP) and mutations are provided. The method uses two specific APEX-2 primers per each SNP or mutations to be determined. The same primers are used in amplification phase (primer extension and PCR with universal primer) and in the single base extension phase on an array. All SNP-containing sequences can be genotyped and amplified in one reaction tube and visualized on a microarray.
REFERENCES:
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patent: 6448020 (2002-09-01), Toftgard et al.
Shumaker, J.M. et al. 2001. APEX disease gene resequensing: Mutation in exon 7 of the p53 tumor suppressor gene. Bio Organic and Medical Chemistry 9 (9) 2269-2278.
Kurg A. et al. 2000. Arrayed primer extension: solid-phase four color DNA resequencing. adn mutation detection tech. Genetic testing, Larchmont NY US vol. 4, No. 1 pp. 1-7.
Tebbut, Scot J. et al. 2005. SNP Chart: an integrated platform for visualizatonand interpretation of microarray genotyping data. Bioinformatics 21(1): 124-127.
Podder Mohua et al. 2006. Dynamic variable selection in SNP genotype autocallign from APEX microarray data. BMC Bioinformatics vol. 7(521) 1471-2105.
Krjutskov Kaarel
Metspalu Andres
Dodds John
Dodds & Associates
Estonian Biocenter
Kim Young J
Somersalo L. Susanne
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