Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-01-10
1998-03-10
Ketter, James
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
536 235, C12Q 168
Patent
active
057260150
ABSTRACT:
This invention relates to a method to determine the metastatic potential of tumor cells. In particular, this invention relates to the detecting of the expression of metalloproteinase pump protein. The expression of this protein can be determined by molecular diagnostic means such as a Northern Blot analysis or polymerase chain reaction amplification. Additionally, immunological methods can be employed to detect metalloproteinase pump protein.
REFERENCES:
patent: 3791932 (1974-02-01), Schuurs et al.
patent: 4244940 (1981-01-01), Jeong et al.
patent: 4376110 (1983-03-01), David et al.
patent: 4677058 (1987-06-01), Tryggvason et al.
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4808528 (1989-02-01), Tryggvason et al.
patent: 4816400 (1989-03-01), Tryggvason et al.
Collier et al., J. Biol. Chem., vol. 263, 1988, pp. 6579-6587.
Garbisa et al., Cancer Res., vol. 47, 1987, pp. 1523-1528.
Quantin et al., Biochemistry, vol. 28, 1989, pp. 5327-5334.
Muller et al., Biochem. J., vol. 253, 1988, pp. 187-192.
Frohman et al., PNAS, vol. 85, 1988, pp. 8998-9002.
Document Number 07/194171 Inventor Stevenson et al.
Ausubel et al., In Current Protocols in Molecular Biology, John Wiley & Sons, pp. 16.8.1-16.11.7, supplement 10, 1990.
Basset et al., A Novel Metalloproteinase Gene Specifically Expressed in Stromal Cells of Breast Carcinomas, Nature 348:699-704 (Dec., 1990).
Harlow et al., Antibodies: A Laboratory Manual, Cold Spring Harbor Laboratory (pp. 53-138 for polyclonal antibodies, and 139-282 for monoclonal antibodies).
Harlow et al., Antibodies: A Laboratory Manual, Cold Spring Harbor Laboratory, pp. 555-612.
Kohler et al., Continuous Cultures of Fused Cells Secreting Antibody of Predefined Specificity, Nature 256:495-497 (1975).
Liotta et al., Metastatic Potential Correlates with Enzymatic Degradation of Basement Membrane Collagen, Nature 284:67-68 (1980).
Matrisian I, Metalloproteinases and Their Inhibitors in Matrix Remodeling, Trends in Genetics 6:121-125 (1990).
Matrisian et al. II, Stromelysin/Transin and Tumor Progression, Cancer Biol. 1:107-115 (1990).
Matrisian et al. III, The mRNA Coding for the Secreted Protease Transin is Expressed More Abundantly in Malignant than in Benign Tumors, Proc. Natl. Acad. Sci, USA 83:9413-9417 (1986).
McDonnell et al., Stromelysin in Tumor Progression and Metastasis, Cancer & Metastasis Reviews, 9:305-319 (1990).
Miyazaki et al., Purification and Characterization of Extracellular Matrix-Degrading Metalloproteinase, Matrin (Pump-1), Secreted from Human Rectal Carcinoma Cell Line, Cancer Res. 50:7758-7764 (1990).
Pajouh et al., Expression of Metalloproteinase Genes in Human Prostate Cancer, J. Cancer Res. Clin. Oncol., 117: (1991).
Woessner et al., Purification and Properties of a Small Latent Matrix Metalloproteinase of the Rat Uterus, J. Biol. Chem., 263:16918-16925 (1988).
Ketter James
McGregor Martin L.
Vanderbilt University
LandOfFree
Method to determine metastatic potential of tumor cells does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method to determine metastatic potential of tumor cells, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method to determine metastatic potential of tumor cells will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-138257