Method to detect T-antigen delayed hypersensitivity

Details Method to detect T-antigen delayed hypersensitivity Method to detect T-antigen delayed hypersensitivity

1987-08-17

1989-08-08

Dixon, Jr., William R.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

A61K 4900, G01N 3348

Patent

active

048551260

ABSTRACT:
Processes are provided for the synthesis of the human T-antigenic determinant 2-acetamido-2-deoxy-3-O-(.beta.-D-galactopyranosyl)-.alpha.-D-galactopyran oside containing an .alpha.-O-glycosidically linked bridging arm O--(CH.sub.2).sub.n COR. The determinant is coupled to carrier molecules to form artificial T-antigens, and to insoluble supports to form T-immunoadsorbents. The artificial T-antigen is shown to elicit a delayed type hypersensitivity reaction as a diagnostic for the presence of cancer in humans.

REFERENCES:
patent: 4311688 (1982-01-01), Burchiel
patent: 4351823 (1982-09-01), Rubin

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