Method to detect IgE

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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435 6, 435 71, 435 72, 435 721, 435 73, 435 731, 435 732, 435 75, 435 79, 435 793, 435 794, 435 795, G01N 3353, G01N 33567, G01N 33554, C12Q 168

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059452943

ABSTRACT:
The present invention includes a method to detect IgE using a human Fc epsilon receptor (Fc.sub..epsilon. R) to detect IgE antibodies in a biological sample from a cat, a dog, or a horse. The present invention also relates to kits to perform such methods.

REFERENCES:
patent: 4962035 (1990-10-01), Leder et al.
Nabamura, R.M. et al., Handbook of Exp. Immunol. in Four Volumes, vol. 1: Immunochemistry, ed. D.M. Weir, Chapt. 27, pp. 27.1-27.20, Jan. 1987.
Suto, Hajime et al, Jpn J. Dermatol, 106:1377-1384, 1996.
Kochan, et al., "Isolation of the Gene Coding for the Alpha Subunit of the Human High Affinity IgE Receptor," (1988) Nucleic Acids Res. 16(8), p. 3584.
Kuster, et al., "Characterization and Expression of the Gene for the Human Fc Receptor .gamma.Subunit," (1990) J. Biol. Chem. 265(11), pp. 6448-6452.
Kuster, et al., "The Gene and cDNA for the Human High Affinity Immunoglobulin E Receptor .beta.Chain and Expression of the Complete Human Receptor," (1992) J. Biol. Chem. 267(18), pp. 12782-12787.
Lowenthal, et al., "Passive Transfer of IgE-Mediated Cutaneous Reactivity in Heterologous Species," (1993) Annals of Allergy 71, pp. 481-484.
Pang, et al., "Characterization of the Gene for the Human High Affinity IgE Receptor (Fc.epsilon.RI) .alpha.-Chain," (1993) J. Immunol. 151(11), pp. 6166-6174.
Shimizu, et al., "Human and Rat Mast Cell High-Affinity Immunoglobulin E Receptors: Characterization of Putative .alpha.-Chain Gene Products," (1988), Proc. Natl. Acad. Sci. USA (85), pp. 1907-1911.

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