Method to detect bone and other connective tissue disorders in h

Details Method to detect bone and other connective tissue disorders in h Method to detect bone and other connective tissue disorders in h

1995-06-06

1997-12-23

Wolski, Susan

Chemistry: analytical and immunological testing

Cancer

435 792, 435 794, 435 723, 436531, 436 86, 436 87, 436161, 436811, 436813, 436815, G01N 3348

Patent

active

057006946

ABSTRACT:
The invention is directed to methods to assess connective tissue, especially bone, metabolism in disease or to monitor therapy, which method comprises assessing the levels of native free collagen-derived crosslinks in biological fluids, especially urine. The method can be enhanced by concomitantly determining the levels of an indicator of bone formation in biological fluids of the same individual and assessing the differences between the degradation marker and the formation indicator. Antibodies which are specifically immunoreactive with forms of crosslinks which occur free in biological fluids are also disclosed.

REFERENCES:
patent: 4973666 (1990-11-01), Eyre
patent: 5140103 (1992-08-01), Eyre
Black, D., et al., "Quantitative Analysis of the Pyridinium Crosslinks of Collagen in Urine Using Ion-Paired Reversed-Phase High-Performance Liquid Chromatography," Anal. Biochem. 169:197-203 (1988).
Black, D., et al., "Urinary Excretion of the Hydroxypyridinium Crosslinks of Collagen in Patients with Rheumatoid Arthritis," Ann. Rheumat. Dis. 48:641-644 (1989a).
Black, D., et al., "Excretion of Pyridinium Cross-Links in Ovariectomized Rats as Urinary Makers for Increased Bone Resorption," Calcif. Tissue Int. 44:343-347 (1989b).
Eyre, D., et al., "Identification of Urinary Peptides Derived from Crosslinking Sites in Bone Collagen in Paget's Disease," J. Bone & Min. Res. 3(1):S210, Abstract No. 565 (1988).
Eyre, D.R., et al., "Quantitation of Hydroxypyridinium Crosslinks in Collagen by High-Performance Liquid Chromatography," Anal. Biochem. 137:380-388 (1984).
Fujimoto, D., et al., "Isolation and Characterization of a Fluorescent Material in Bovine Achilles Tendon Collagen," Biochem. & Biophys. Res. Commun. 76(4):1124-1129 (1977).
Fujimoto, D., et al., "The Structure of Pyridinoline, a Collagen Crosslink," Biochem. & Biophys. Res. Commun. 84(1):52-57 (1978).
Fujimoto, D., and Moriguchi, T., "Pyridinoline, a Non-Reducible Crosslink of Collagen," J. Biochem. 83:863-867 (1978).
Fujimoto, D., et al., "Analysis of Pyridinoline, a Cross-Linking Compound of Collagen Fibers, in Human Urine," J. Biochem. 94:1133-1136 (1983).
Gunja-Smith, Z., and Boucek, R.J., "Collagen Cross-Linking Compounds in Human Urine," Biochem. J. 197:759-762 (1981).
Macek, J., and Adam, M., "Determination of Collagen Degradation Products in Human Urine in Osteoarthrosis," Z. Rheumatol. 46:237-240 (1987).
Ogawa, T., et al., "A Novel Fluor in Insoluble Collagen: A Crosslinking Moiety in Collagen Molecule," Biochem. & Biophys. Res. Commun. 107(4):1252-1257 (1982).
Robins, S.P., "An Enzyme-Linked Immunoassay for the Collagen Cross-Link Pyridinoline," Biochem. J. 207:617-620 (1982).
Robins, S.P., "Turnover and Crosslinking of Collagen," in Collagen in Health and Disease (Weiss, J.B., et al., Eds.) Churchill Livingston, Edinburgh, Scotland, pp. 160-178 (1982).
Robins, S.P., "Cross-Linking of Collagen," Biochem. J. 215:167-173 (1983).
Robins, S.P., and Duncan, A., "Cross-Linking of Collagen," Biochem. J. 215:175-182 (1983).
Robins, S.P., et al., "Measurement of the Cross Linking Compound, Pyridinoline, in Urine as an Index of Collagen Degradation in Joint Disease," Ann. Rheumat. Dis. 45:969-973 (1986).
Robins, S.P., and Duncan, A., "Pyridinium Crosslinks of Bone Collagen and Their Location in Peptides Isolated from Rat Femur," Biochim. et Physiophys. Acta 914:233-239 (1987).
Robins, S.P., et al., "Urinary Hydroxy-Pyridinium Crosslinks of Collagen as markers of Resorption in a Range of Metabolic Diseases," J. Mineral & Bone Res. 4:S397 (1989).
Seibel, M.J., et al., "Urinary Hydroxy-Pyridinium Crosslinks Provide Indices of Cartilage and Bone Involvement in Arthritic Diseases," J. Rheumatol. 16(7):964-970 (1989).
Wu, J.-J., and Eyre, D.R., "Identification of Hydroxypyridinium Cross-Linking Sites in Type II Collagen of Bovine Articular Cartilage," Biochemistry 23:1850-1857 (1984).

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