Method to destroy malignant cells in mononuclear cell population

Details Method to destroy malignant cells in mononuclear cell population Method to destroy malignant cells in mononuclear cell population

1990-02-20

1992-02-11

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

424 9, 514 2, 540145, A61K 3140

Patent

active

050876368

ABSTRACT:
A method to prepare bone marrow or other hemopoietic cells free of malignant cells for autologous transplants is described. The mononuclear cells from the marrow are treated with a green porphyrin (Gp) to effect the uptake of said Gp by malignant cells selectively, and then irradiated with a wavelength of light absorbed by said Gp to effect the destruction of the malignant cells. The purged marrow cells can then be used for autologous transplantation.

REFERENCES:
patent: 4883790 (1989-11-01), Levy et al.
patent: 4920143 (1990-04-01), Levy et al.
Gale et al., Seminars in Hematology (1987) 24:40-54.
Champlin et al., Seminars in Hematology (1987) 24:55-67.
Champlin et al., Seminars in Hematology (1988) 25:74-80.
Malik et al., Brit. J. Cancer (1987) 56:589-595.
Sieber et al, Blood (1986) 68:32-36.
Sieber et al., Photochem. Photobiol. (1987) 46:71-76.
Singer et al., Brit. J. Hematol. (1988) 68:417-422.
Talpaz et al., Seminars in Hematology (1988) 25:62-73.
Jamieson et al., SPIE Photodynamic Therapy: Mechanisms (1989) 1065:152-163.

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