Method to derivatize dextran

Details Method to derivatize dextran Method to derivatize dextran

1987-12-24

1990-12-04

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536112, 436529, 514 59, C08B 3702

Patent

active

049755323

ABSTRACT:
A method to convert the hydroxyl groups of solubilized dextran to the tresylate forms which can be displaced by a nucleophile is disclosed. The method of the invention requires the reaction of dextran with the tresylating reagent in the presence of dry DMSO. The resulting tresylate can be converted to labeled dextrans which have direct linkages of a nucleophilic label to the carbons of the dextran backbone.

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