Method to assess the ability of a substance to inhibit or stimul

Details Method to assess the ability of a substance to inhibit or stimul Method to assess the ability of a substance to inhibit or stimul

1990-07-26

1993-11-16

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

436 63, 435 29, C12Q 168, C12Q 102, G01N 3348

Patent

active

052622983

ABSTRACT:
Keratinocyte autocrine factor (KAF) can be isolated from human keratinocytes and is an effective and selective mitogen for keratinocytes in comparison to fibroblasts. Methods of purifying KAF using sulfated glycosaminoglycans, methods to inhibit the effect of KAF using sulfated glycosaminoglycans, and methods to assay for stimulators and inhibitors of KAF activity and production are described.

REFERENCES:
Shipley et al., Archives of Dermatology (1987) 123:1541a-1544a.
Shipley et al., J. Cellular Phys. (1989) 138:511-518.
Shipley et al., J. Tissue Culture Methods (1986) 10(2):117-123.
Rubin et al., Proc. Natl. Acad. Sci. (1989) 86:802-806.
Halper et al., Cancer Res. (1987) 47:4552-4559.
Masuda et al., In Vitro Cellular & Developmental Biology (1988) 24(9):893-899.
Masuda et al., Cell Biology International Reports (1987) 11(5):359-365.
Shoyab et al., Proc. Natl. Acad. Sci. (1988) 85:6528-6532.
Shoyab et al., Science (1989) 243:1074-1076.
Plowman et al., Mol. & Cell. Biol. (1990) 10(5):1969-1981.

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