Chemistry: analytical and immunological testing – Including chromatography
Reexamination Certificate
2007-12-04
2007-12-04
Gakh, Yelena G. (Department: 1743)
Chemistry: analytical and immunological testing
Including chromatography
C435S004000
Reexamination Certificate
active
10444535
ABSTRACT:
A method is described for determining CoQ10concentrations in plasma samples. CoQ10in the plasma sample is oxidized by treating the sample with an oxidizing agent having a redox potential higher than the redox potential of CoQ10, such as, for example, para-benzoquinone. Following oxidation of the CoQ10, the CoQ10in the plasma sample is extracted with an alcohol, such as, for example, 1-propanol. The alcohol extract is analyzed using direct injection into the HPLC apparatus. This method achieves a rapid, accurate analysis of plasma CoQ10levels, which can be used for monitoring the bioavailability of orally administered CoQ10used as a food supplement or as an adjunctive therapy.
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Bompadre Stefano
Fattorini Daniele
Littarru Gian Paolo
Mosca Fabrizo
Gakh Yelena G.
McCarter & English LLP
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