Method to ameliorate osteolysis and metastasis

Details Method to ameliorate osteolysis and metastasis Method to ameliorate osteolysis and metastasis

1995-01-23

1997-05-06

Rollins, John W.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

4241581, 4241301, 514885, A61K 39395

Patent

active

056268459

ABSTRACT:
Materials immunoreactive with parathyroid hormone-related protein (PTH-rp) are used in the invention method to prevent and treat metastasis and cancer cell growth in bone as well as osteolysis and symptomatic sequelae thereof. Humanized antibodies are included in the invention for application of the invention method to human subjects.

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Guise et al., "Parathyroid hormone-related protein (PTHrP) expression by breast cancer cells enhance osteolytic bone metastases in vivo" Breast Cancer Res. Treat., 32(supppl): 91 (1994).

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