Method to aid in the diagnosis of alzheimer's disease

Details Method to aid in the diagnosis of alzheimer's disease Method to aid in the diagnosis of alzheimer's disease

1992-07-28

1995-03-14

Bidwell, Carol E.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

435 71, 435 721, 436530, 436531, 436811, G01N 3353, G01N 33543

Patent

active

053977122

ABSTRACT:
A method to aid in the diagnosis of Alzheimer's disease in a living patient is disclosed which tests cerebrospinal fluid (CSF) obtained from the patient. The CSF is tested using a Western blot analysis to determine the presence of an antigen present in soluble paired helical filaments which specifically binds to the monoclonal antibody produced by hybridoma ATCC HD11079.

REFERENCES:
Selkoe et al, Alzheimer's and Parkinson's Diseases, Fisher et al (Ed), 37-38 (1986).
Selkoe, D. J., Neurobiol. of Aging, 7:425-432 (1986).
B. M. Biochemicals, p. 68 (1991).
Mehta, et al, The Lancet, Jul. 6, 1985, p. 35.
Ihara et al, Nature, 304:727-730 (1983).
Vogelsang et al: Journal of Neurochemistry, vol. 54, No. 1, 1990, pp. 148-155.
Ghanbari et al.: Journal of the American Medical Publication, vol. 263, No. 21, pp. 2907-2910.

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