Method, system, and apparatus for cardiovascular signal...

Surgery – Diagnostic testing – Cardiovascular

Reexamination Certificate

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Reexamination Certificate

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08057398

ABSTRACT:
Disclosed embodiments of the invention include a method, system, and apparatus to monitor cardiovascular signals such as arterial blood pressure (ABP), pulse oximetry (POX), and intracranial pressure (ICP).The system can be used to calculate and monitor useful clinical information such as heart rate, respiratory rate, pulse pressure variation (PPV), harmonic phases, pulse morphology, and for artifact removal. The method uses a statistical state-space model of cardiovascular signals and a generalized Kalman filter (EKF) to simultaneously estimate and track the cardiovascular parameters of interest such as the cardiac fundamental frequency and higher harmonics, respiratory fundamental frequency and higher harmonics, cardiac component harmonic amplitudes and phases, respiratory component harmonic amplitudes and phases, and PPV.

REFERENCES:
patent: 6413223 (2002-07-01), Yang et al.
patent: 7215986 (2007-05-01), Diab et al.
patent: 2002/0137994 (2002-09-01), Baker et al.
McNames et al., “Cardiovascular Signal Decomposition and Estimation with the Extended Kalman Smoother”, Aug. 30-Sep. 3, 2006, Proceedings of the 28th IEEE: EMBS Annual International Conference, p. 3708-3711.
Van Der Mewre, Rudolph; “Sigma-Point Kalman Filters for Probabilistic Inference in Dynamic State-Space Models”; Apr. 2004; dissertation submitted to OGI School of Science & Engineering at Oregon Health & Science University.
McNames J; Aboy M; “Cardiovascular Signal Decomposition and Estimation with the Extended Kalman Smoother”, EMBS Annual International Conference, Aug. 30-Sep. 3, 2006.

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