Method, reagent and kit for malaria testing

Details Method, reagent and kit for malaria testing Method, reagent and kit for malaria testing

2009-03-16

2011-10-11

Nickol, Gary (Department: 1645)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

C435S007100

Reexamination Certificate

active

08034551

ABSTRACT:
The present invention provides a method for malaria testing which enables testing for the presence of malaria infection and the extent of the infection in a convenient manner; and a reagent or kit which can be used in the method. The method for malaria testing according to the present invention includes the step of detecting a liver-type fatty acid binding protein present in urine collected from a subject animal. The extent of infection is determined to be higher when a larger amount of the liver-type fatty acid binding protein is present in a test sample.

REFERENCES:
patent: 2007/0243560 (2007-10-01), Yamanouchi et al.
patent: 2006-304774 (2006-11-01), None
Mutsuo Kobayashi et al. (2007 Annual Report on Summarized and Shared Individual Research , Principle Researcher Mutsuo Kobayashi, National Institute for Infectious Diseases, Department of Insect Medical Science reported Mar. 21, 2008).
Mikolajczak et al. (international Journal of Parasitology vol. 37, pp. 483-489, 2007).
Matsumoto et al., “Study on Malaria Aggravation Mechanism Using Animal Model—Elucidation of Pathogenic Mechanism of Severe Malaria such as Cerebral Malaria and Search for Biomarker as Indicator for Malaria Aggravation in particular,” Ministry of Health, Labor and Welfare Grant-in-aid Scientific Research Emerging Reemerging Infectious Disease Research Project, Countermeasure Research on the Effective Prevention of Arthropod-borne Infectious Diseases (H18-Emergent-General-009), Mar. 21, 2008, pp. 269-274.
Mikolajczak et al., “L-FABP is a critical host factor for successful malaria liver stage development,” International Journal for Parasitology, 37, 2007, pp. 483-489.
Kamijo et al., “Urinary liver-type fatty acid binding protein as a useful biomarker in chronic kidney disease,” Molecular and Cellular Biochemistry, 284, 2006, pp. 175-182.
Negishi et al., “Renal L-type fatty acid-binding protein mediates the bezafibrate reduction of cisplati-induced acute kidney injury,” Kidney International (original article) pp. 1-11, (http://www.kidney-international.org), 2008.

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