Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1994-10-11
1997-08-19
Zitomer, Stephanie W.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 911, 435 912, 435810, 536 232, 536 243, 536 2431, 536 2433, 536 245, C07H 2104, C12P 1934, C12Q 168
Patent
active
056587295
ABSTRACT:
A single point mutation in the human lipoprotein lipase gene which results in an A.fwdarw.G nucleotide change at codon 291 (nucleotide 1127) of the lipoprotein lipase gene, and a substitution of serine for the normal asparagine in the lipoprotein lipase gene product is seen with increased frequency in patients with coronary artery disease, and is associated with an increased susceptibility to coronary artery disease, including in particular premature atherosclerosis. This is expressed as a diminished catalytic activity of lipoprotein lipase, lower HDL-cholesterol levels and higher triglyceride levels. Thus, susceptibility of a human individual to premature atherosclerosis and other forms of coronary artery disease can be evaluated by
REFERENCES:
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4683202 (1987-07-01), Mullis
patent: 4957858 (1990-09-01), Chu et al.
patent: 5124246 (1992-06-01), Urdea et al.
patent: 5200314 (1993-04-01), Urdea
patent: 5270184 (1993-12-01), Walker et al.
Normand et al. Human Genetics 89:671-675, 1992.
Hayden et al., "Molecular genetics of Human Lipoprotein Lipase Deficiency", Molecular and Cellualr Biochemistry 113: 171-176 (1992).
Ma et al., "High Frequency of Mutation in the Human Lipoprotein Lipase Gene in Pregancy-Induced Chylomicronemia: Possible Association with Apoplipoprotein E2 Isoform", J. Lipid Research 35: 1066-1075 (1994).
Ma et al., "Type III Hyperlipoproteinemia in Apo E2/2 Homozygotes: Possible Role of Mutations in the Lipoprotein Lipase Gene", Circulation, Abstracts from the 66th Scientific Session of American Heart Association 1-179 (1993).
Gordon et al., "High Density Lipoprotein As a Protective Factor Against Coronary Heart Disease" The Amer. J. Med. 62: 707-714 (1977).
Hobbs, et al, "Molecular Genetics of the LDL Receptor Gene in Familial Hypercholesterolemia", Human Mutations 1: 445-466 (1992).
Soria et al., "Association between a specific apolipoprotein B mutation and familial defective apolipoprotein B-100", Proc. Nat'l Acad. Sci. USA 86: 587-91 (1989).
Brown et al., "Molecular Basis of Lipid Transfer Protein Deficiency in a Family With Increased High-Density Lipoproteins", Nature 342: 448-451 (1989).
Rubin et al., "Inhibition of Early Atherogenesis in Transgenic Mice by Human Apolipoprotein A1", Nature 353: 265-266 (1991).
Mullenbach et al. "An efficient salt-chloroform extraction of DNA from blood and tissues", Trend in Genetics 5: 391 (1989).
Oka et al., "Structure and polymorphic map of human lipoprotein lipase gene", Biochim. Biophys. Acta 1049: 21-26 (1990).
Deeb et al., "Structure of the Human Lipoprotein LIpase Gene", Biochemistry 28: 4131-4135 (1989).
Wion et al, "Human Lipoprotein Lipase Complementary DNA Sequence", Science 235: 1638-1641 (1987).
Monsalve et al., "A Missense Mutation at Codon 188 of the Human Lipoprotein LIpase Gene is a Frequent Cause of Lipoprotein Lipase Deficiency in Persons of Different Ancestories", J. Clin. Invest. 86: 728-734 (1990).
Stratford-Perricaudet et al., "Widespread Long-Term Gene Transfer to Mouse Skeletal Muscles and Heart", J. Clin. Invest. 90: 626-630 (1992).
Mulligan et al., "Expression of a Bacterials Gene in Mammalian Cells", Science 209: 1422-1427 (1980).
Liu, et al., "Alteration of Lipid Profiles in PLasma of Transgenic Mice Expressing Human Lipoprotein Lipase", J. Biol. Chem. 269: 11417-11424 (1994).
Tsutsumi et al., "The Novel Compound NO-1886 Increase Lipoproteim Lipase Activity with Resulting Elevation of High Density Lipoprotein Cholesterol, and Long-term Administration Inhibits Atherogenesis in the Coronary Arteries of Rats with Experimental Atherosclerosis", J. Clin. Invest. 92: 411-417 (1992).
Kuusi et al., "Postheparin plasma lipoprotein and hepatic lipase are determinants of hypo- and hyperalphalipoproteinemia", J. Lipid Research 30: .
Taskinen et al., "High Density lipoprotein subfractions in relation to lipoprotein lipase acticity of tissues in man--evidence of reciprocal regulation of HDL2 and HDL3 levels by lipoprotein lipase", Clinica Chimica Acta 112: 325-332 (1981).
Zilversmit, D.B., "A Proposal Linking Atherogenesis to the Interaction of Endothelial Lipoprotein LIpase with Triglyceride-Rich Lipoproteins", Circulation Research 33: 633-638 (1973).
Hayden Michael R.
Lewis Suzanne
Liu Guoquing
Ma Yuanhong
The University of British Columbia
Tran Paul B.
Zitomer Stephanie W.
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