Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Reexamination Certificate
2011-07-26
2011-07-26
Duffy, Patricia A (Department: 1645)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
C530S388400
Reexamination Certificate
active
07985410
ABSTRACT:
The purpose of the present invention is to provide a method and an agent to efficiently inhibit the function of the drug efflux pump ofPseudomonas aeruginosa. The invention provides a method to inhibit the function of the drug efflux pump ofPseudomonas aeruginosa, comprising modifying any amino acid residue selected from 100th to 109th or 311th to 320th amino acid residues in the amino acid sequence of mature OprM protein. The invention also provides an agent having such inhibitory effect, and a screening method thereof.
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Li, et al., Mutational analysis of the OprM outer membrane component of the MexA-MexB-OprM multidrug efflux system ofPseudomonas aeruginosa, J Bacteriol. Jan. 2001;183(1), p. 12-27.
Wong, et al., Insertion Mutagenesis and Membrane Topology Model of thePseudomonas aeruginosaOuter Membrane Protein OprM, Journal of Bacteriology, May 2000, p. 2402-2410, vol. 182, No. 9.
Wong, et al., Evaluation of a Structural Model ofPseudomonas aeruginosaOuter Membrane Protein OprM, an Efflux Component Involved in Intrinsic Antibiotic Resistance, Journal of Bacteriology, Jan. 2001, p. 367-374, vol. 183, No. 1.
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Inoko Hidatoshi
Yoshihara Eisaku
Bozicevic Field & Francis LLP
Duffy Patricia A
Franis Carol L.
Tokai University
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