Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2009-03-17
2010-06-08
Whiteman, Brian (Department: 1635)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
Reexamination Certificate
active
07732594
ABSTRACT:
The present invention provide a method for analyzing the DSG3 overexpression in tumor tissues with clinical features of cancer cells to validate that overexpression is relates to size, depth and migration of tumor. Therefore, DSG3 overexpression is capable for using in clinical applications, determining malignant degree of tumor, serving as molecular target in Head Neck Cancer (HNC). Moreover, a jamming sequence, RNA, is designed to act on DSG3 mRNA and is effective inhibition-specific DSG3 expression, and then inhibits cell growth, invasion and migration in HNC.
REFERENCES:
patent: 2003/0108890 (2003-06-01), Baranova
patent: 2006/0019290 (2006-01-01), Godfrey
patent: 2006/0241075 (2006-10-01), McSwiggen
Chang Joseph Tung-Chieh
Chen Yin-Ju
Cheng Ann-Joy
Chang Gung Memorial Hospital
Chang Gung University
Whiteman Brian
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