Method on clinical applications in head neck cancer by using...

Details Method on clinical applications in head neck cancer by using... Method on clinical applications in head neck cancer by using...

2006-11-06

2009-11-24

Whiteman, Brian (Department: 1635)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

Reexamination Certificate

active

07622456

ABSTRACT:
The present invention provide a method for analyzing the DSG3 overexpression in tumor tissues with clinical features of cancer cells to validate that DSG3 overexpression is relates to size, depth and migration of tumor. Therefore, DSG3 overexpression is capable for using in clinical applications, determining malignant degree of tumor, serving as molecular target in Head Neck Cancer (HNC). Moreover, a jamming sequence, RNA, is designed to act on DSG3 mRNA and is effective inhibition-specific DSG3 expression, and then inhibits cell growth, invasion and migration in HNC.

REFERENCES:
patent: 2003/0108890 (2003-06-01), Baranova et al.
patent: 2006/0019290 (2006-01-01), Godfrey et al.
patent: 2006/0241075 (2006-10-01), McSwiggen

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