Method of verifying the synthesis of organic molecules using...

Electricity: measuring and testing – Particle precession resonance – Using a nuclear resonance spectrometer system

Reexamination Certificate

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C324S076490, C706S048000

Reexamination Certificate

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07064543

ABSTRACT:
A NMR method to verify the presence of organic molecular compounds consisting of repetitive occurring individual structures is presented. The method comprises the steps of assigning structure codes to the selected compounds, in accordance with the respective starting compounds used, measuring multi-dimensional NMR spectra from at least some of the compounds, uniquely assigning signal groups of NMR spectra to the individual structures, checking the NMR spectra of the compounds for the presence of all assigned signal groups, and characterizing a particular compound as being TRUE if the check of its particular combination of structures yields the result that the signal groups of structures contained in its total code had been observed. The method permits rapid and accurate verification of the presence of compounds having repetitive structures such as those produced in combinatorial chemistry.

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Braun, S.; Kalinowski, H. -O. Berger, S. 150 and More Basic NMR Experiments. New York: Wiley-VCH, Jun. 1998, p. 401.
Newkome, G. R.; Weis, C. D.; Moorefield, C. N.; Baker, G. R.; Childs, B. J.; Epperson J. Isocyanate-Based Dendritic Building Blocks: Combinatorial Tier Construction and Macromolecular-Property Modification Angew. Chem. Int. Ed. Feb. 1998, 37(3), 307-3.
Will, M.; Fachinger, W.; Richert, J. R. “Fully Automated Structure Elucidation—A spectroscopist's Dream Comes True” J. Chem. Inf. Compout. Sci. 1996, 36, 221-227.
Will M. et al.: “Fully automated structure elucidation—A spectrocopist's dream comes true”. Journal of Chemical Information and Computer Sciences, American Chemical Society, vol. 36, 1996, pp. 221-227, XP002290864 Chapter “Discussion”, Conclusion and outlock Figs. 2, 5, 6.
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