Method of vaccine or toxoid preparation and immunization by colo

Details Method of vaccine or toxoid preparation and immunization by colo Method of vaccine or toxoid preparation and immunization by colo

1989-11-01

1992-09-22

Stone, Jacqueline

Drug, bio-affecting and body treating compositions

Lymphokine

424 93A, 435 693, 4351723, 4352523, 4352529, 935 12, 935 65, 935 72, A61K 39245, C12N 2100, C12N 1538

Patent

active

051495325

ABSTRACT:
A method of vaccine or toxoid preparation and immunization against pathogenic disease. An area of the body is colonized with indigenous microorganisms that have been transformed by recombinant DNA technology to express pathogenic antigens. The colonized transformant microorganisms will replicate and elicit an immune response to the pathogenic antigen, thereby protecting the individual from subsequent exposure to the intact pathogen.

REFERENCES:
patent: 4888170 (1989-12-01), Curtiss, III
Watanabe, Biol. Abstracts vol. 81 (1986) No. 111724.
Amann et al., Gene, 40 (1985) 183-190.

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