Method of vaccination comprising administering an antigen...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C424S185100, C424S278100, C514S002600

Reexamination Certificate

active

07658928

ABSTRACT:
Described is a vaccine which comprises at least one antigen and at least one cathelicidin derived antimicrobial peptide or a derivative thereof as well as the use of a cathelicidin derived antimicrobial peptide or a derivative thereof for the preparation of an adjuvant for enhancing the immune response to at least one antigen.

REFERENCES:
patent: 6103888 (2000-08-01), Larrick et al.
patent: 6335318 (2002-01-01), Selsted et al.
patent: 6821519 (2004-11-01), Day et al.
patent: 2002/0197269 (2002-12-01), Lingnau et al.
patent: 0974360 (2000-01-01), None
patent: WO 01/54720 (2001-08-01), None
Agerberth et al., “Antibacterial components in bronchoalveolar lavage fluid from healthy individuals and sarcoidosis patients,”Am. J. Respir. Crit. Care Med., 160:283-290, 1999.
Agerberth et al., “The human antimicrobial and chemotactic peptides LL-37 and α-defensins are expressed by specific lymphocyte and monocyte populations,”Blood, 96:3086-3093, 2000.
Altfeld et al., “Identification of Dominant Optimal HLA-B60- and HLA-B61-Restricted Cytotoxic T-Lymphocyte (CTL) Epitopes: Rapid Characterization of CTL Responses by Enzyme-Linked Immunospot Assay,”J. Virology, 74:8541-8549, 2000.
Altschul et al., “Gapped BLAST and PSI-BLAST: a new generation of protein database search programs,”Nucleic Acids Research, 25:3389-3402, 1997.
Andreu and Rivas, “Animal antimicrobial peptides: an overview,”Biopoly, 47:415-433, 1998.
Attwood, “Genomics. The Babel of bioinformatics,”Science, 290:471-473, 2000.
Bagella et al., “cDNA sequences of three sheep myeloid cathelicidins,”FEBS Letters, 376:225-228, 1995.
Bals et al., “Augmentation of innate host defense by expression of a cathelicidin antimicrobial peptide,”Infection and Immunity, 67(11):6084-6089, 1999.
Bals et al., “The peptide antibiotic LL-37/hCAP-18 is expressed in epithelia of the human lung where it has broad antimicrobial activity at the airway surface,”Proc. Natl. Acad. Sci., USA, 95:9541-9546, 1998.
Banchereau and Steinman, “Dendritic cells and the control of immunity,”Nature, 392:245-252, 1998.
Banchereau et al., “Immunobiology of dendritic cells,”Annu. Rev. Immunol., 18:767-811, 2000.
Basak et al., “Histidine-rich human salivary peptides are inhibitors of proprotein convertases furin and PC7 but act as substrates for PC1,”J. Peptide Res., 49:596-603, 1997.
Befus et al., “Neutrophil defensins induced histamine secretion from mast cells: mechanisms of action,”J. Immunology, 163:947-953, 1999.
Berzofsky et al., “Progress on new vaccine strategies against chronic viral infections,”J. Clin. Invest., 114:450-462, 2004.
Bloom et al., “Identification of tyrosinase-related protein 2 as a tumor rejection antigen for the B16 melanoma,”J. Exp. Med., 185:453-459, 1997.
Boman, “Antibacterial peptides: key components needed in immunity,”Cell, 65:205-207, 1991.
Boman, “Innate immunity and the normal microflora,”Immunological Reviews, 173:5-16, 2000.
Bradbury and Smyth, “Peptide amidation,”TIBS, 16:112-115, 1991.
Brossart and Bevan, “Presentation of exogenous protein antigens on major histocompatability complex class I molecules by dendritic cells: pathway of presentation and regulation by cytokines,”Blood, 90:1594-1599, 1997.
Buschel et al., “Chemically defined, cell-free cancer vaccines: use of tumor antigen-derived peptides of polyepitope proteins for vaccination,”Gene Therapy and Molecular Biology, 1:309-321, 1998.
Buschle et al., “Transloading of tumor antigen-derived peptides into antigen-presenting cells,”Proc. Natl. Acad. Sci., USA, 94:3256-3261, 1997.
Chan and Gallo, “PR-39, a syndecan-inducing antimicrobial peptide, binds and affects p130,”J. Biol. Chem., 273:28978-28985, 1998.
Chertov et al., “Identification of defensin-1, defensin-2, and CAP37/Azurocidin as T-cell chemoattractant proteins released from interleukin-8-stimulated neturophils,”J. Biol. Chem., 271:2935-2940, 1996.
Cole et al., “Inhibition of neutrophil prevents cathelicidin activation and impairs clearance of bacterial from wounds,”Blood, 97:297-304, 2001.
Cowland et al., “hCAP-18, a cathelin/pro-bactenecin-like protein of human neutrophil specific granules,”FEBS Letters, 368:173-176, 1995.
Cox and Coulter, “Adjuvants—a classification and review of their modes of action,”Adjuvants Vaccine, 15:248-256, 1997.
Del Sal et al., “cDNA cloning of the neutrophil bactericidal peptide indolicidin,”Biochem. Biophys. Res. Comm., 187:467-472, 1992.
Ezzell,NIH Research, 7:46-49, 1995.
Falla et al., “Mode of action of the antimicrobial peptide indolicidn,”J. Biol. Chem., 271:19298-19303, 1996.
Fallarino et al., “Improved efficacy of dendritic cell vaccines and successful immunization with tumor antigen peptide-pulsed peripheral blood mononuclear cells by coadministration of recombinant murine interleukin-12,”Int. J. Cancer, 80:324-333, 1999.
Frohm et al., “The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders,”J. Biol. Chem., 272:15258-15263, 1997.
Frohm Nilsson et al., “The human cationic antimicrobial protein (hCAP18), a peptide antibiotic, is widely expressed in human squamous epithelia and colocalizes with interleukin-6,”Infection and Immunity, 67:2561-2566, 1999.
Gallo et al., “Identification of CRAMP, a cathelin-related antimicrobial peptide expressed in the embryonic and adult mouse,”J. Biol. Chem., 272:13088-13093, 1997.
Gallo et al., “Syndecans, cell surface heparan sulfate proteoglycans, are induced by a proline-rich antimicrobial peptide from wounds,”Proc Natl. Acad. Sci., USA, 91:11035-11039, 1994.
Ganz and Lehrer, “Antibiotic peptides from higher eukaryotes: biology and applications,”Molecular Medicine Today, 5:292-297, 1999.
Ganz and Lehrer, “Antimicrobial peptides of leukocytes,”Current Opinion in Hematology, 4:53-58, 1997.
Ganz and Lehrer, “Antimicrobial peptides of vertebrates,”Current Biology, 10:41-44, 1998.
Ganz and Lehrer, “Defensins,”Current Opinion in Immunology, 6:584-589, 1994.
Garcia et al., “Human β-defensin 4: a novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity,”FASEB, 15:1819-1821, 2001.
Gennaro et al., “Biological characterization of a novel mammalian antimicrobial peptide,”Biochimica et aBiophysica Acta, 1425:361-368, 1998.
Giangaspero et al., “Amphipathic alpha helical antimicrobial peptides: a systematic study of the effects of structural and physical properties on biological activity,”Eur J Biochem, 268:5589-5560, 2001.
Gough et al., “Antiendotoxin activity of cationic peptide antimicrobial agents,”Infection and Immunity, 64:4922-4927, 1996.
Goulder et al., “Rapid Definition of Five Novel HLA-A*3002-Restricted Human Immunodeficiency Virus-Specific Cytotoxic T-Lymphocyte Epitopes by Elispot and Intracellular Cytokine Staining Assays,”J. Virology, 75:1339-1347, 2001.
Gudmundsson and Agerberth, “Neutrophil antibacterial peptides, multifuctional effector molecules in the mammalian immune system,”J. of Immunological Methods, 232:45-54, 1999.
Gudmundsson et al., “The human gene FALL39 and processing of the cathelin precursor the antibacterial peptide LL-37 in granulocytes,”Eur. J. Biochem., 238:325-332, 1996.
Hancock and Diamond, “The role of cationic antimicrobial peptides in innate host defences,”Trends in Microbiology, 8:402-410, 2000.
Hancock and Scott, “The role of anitmicrobial peptides in animal defenses,”Proc. Natl. Acad. Sci., USA, 97:8856-8861, 2000.
Hancock, “Host defence (cationic) peptides

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method of vaccination comprising administering an antigen... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of vaccination comprising administering an antigen..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of vaccination comprising administering an antigen... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4198172

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.