Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector
Reexamination Certificate
2007-01-09
2007-01-09
Chan, Christina (Department: 1644)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
C424S185100, C424S277100
Reexamination Certificate
active
10705660
ABSTRACT:
The invention provides a vaccine composition and a method of preparation including the steps of: forming a water-in-oil emulsion including an alginate in water, an oil, an antigen, and either (a) a cellulose ether and at least one nonionic surfactant or (b) a PEO-PPO-PEO triblock copolymer surfactant and at least one nonionic surfactant; followed by crosslinking the alginate in the emulsion with at least two cations selected from the group consisting of aluminum, barium, calcium, lithium, manganese, strontium, and zinc, to form antigen-containing, crosslinked alginate microparticles; and harvesting the microparticles. Another aspect of the invention is a method of vaccinating a vertebrate species including the step of administering to the species a vaccine composition prepared according to the method of the invention. The compositions of the invention have improved antigen loading, reduced microparticle size, increased hydrophobicity, improved uptake by antigen sampling cells, controlled antigen release characteristics, and improved immunogenicity.
REFERENCES:
patent: 3551556 (1970-12-01), Kliment et al.
patent: 3880990 (1975-04-01), Bauer et al.
patent: 4178361 (1979-12-01), Cohen et al.
patent: 4220152 (1980-09-01), Dresback
patent: 4352883 (1982-10-01), Lim
patent: 4391909 (1983-07-01), Lim
patent: 4673566 (1987-06-01), Goosen et al.
patent: 4689293 (1987-08-01), Goosen et al.
patent: 4780315 (1988-10-01), Wu et al.
patent: 4792452 (1988-12-01), Howard et al.
patent: 4798786 (1989-01-01), Tice et al.
patent: 4803168 (1989-02-01), Jarvis, Jr.
patent: 4806355 (1989-02-01), Goosen et al.
patent: 4808404 (1989-02-01), Bhogal
patent: 4873090 (1989-10-01), Clancy
patent: 5019100 (1991-05-01), Hennink et al.
patent: 5075109 (1991-12-01), Tice et al.
patent: 5352448 (1994-10-01), Bowersock et al.
patent: 5674495 (1997-10-01), Bowersock et al.
patent: 6214331 (2001-04-01), Vanderhoff et al.
patent: 6656470 (2003-12-01), Bowersock et al.
patent: 0 188 309 (1986-07-01), None
patent: 0 540 413 (1993-05-01), None
patent: 1-313437 (1989-12-01), None
patent: WO 85/00752 (1985-02-01), None
patent: WO 95/02416 (1995-01-01), None
patent: WO 98/46211 (1998-10-01), None
patent: WO 01/00233 (2001-01-01), None
Bowersock et al., “Evaluation of an orally administered vaccine, using hydrogels containing bacterial exotoxins ofPasteurella hoemolytica, in cattle”,American Journal of Veterinary Research, vol. 55, No. 4, pp. 502-509 (1994).
Bowersock et al., “Oral Administration of Mice with Ovalbumin Encapsulated in Alginate Microspheres”.Abstracts of Papers of the American Chemical Society. vol. 208 (1994).
Bowersock et al., “Oral Vaccination of Animals Via Hydrogels”,Proceed. Intern. Symp. Control. Rel. Bioact. Mater., vol. 21 (1994).
Bowersock et al., “Uptake of Alginate Microspheres by Peyer's Patches”,Proceed Intern. Symp. Control. Rel. Bioact. Mater., vol. 21 (1994).
Offit et al., “Enhancement of Rotavirus Immunogenicity by Microencapsulation”,Virology, vol. 203, pp. 134-143 (1994).
Suckow et al., “Stimulation of Immunity toPasteurella multocidain Rabbits by Oral Immunization Using a Microsphere Delivery System”,Proceed. Intern. Symp. Control. Rel. Bioact. Mater., vol. 21 (1994).
Jackson, R. “Aliginate Microspheres for Oral Delivery of Vaccines” a Thesis Submitted to the Faculty of Purdue University (1995).
Khoury et al., “Oral Inoculation of Mice with Low Doses of Microencapsulated, Noninfectious Rotavirus Induces Virus-Specific Antibodies in Gut-Associated Lymphoid Tissue”,The Journal of Infectious Diseases, vol. 172, pp. 870-874 (1995).
Bowersock et al., “Adminstration of Ovalbumin Encapsulated in Alginate Microspheres to Mice”, Chapter 6 in “Hydrogels and biodegradable polymers for bioapplications”,American Chemical Society, pp. 58-66 (1996).
Duncan et al., “Comparative analysis of oral delivery systems for live rotavirsu vaccines”,Journal of Controlled Release, vol. 41, pp. 237-247 (1996).
HogenEsch et al., “Systemic and pulmonary immune response to intrabronchial administration of ovalbumin in calves”,Veterinary Immunology and Immunopathology, vol. 51, pp. 293-302 (1996).
Moser et al., “Aqueous-based microencapsulation enhances virus-specific humoral immune responses in mice after parenteral inoculation”,Vaccine, vol. 14, No. 13, pp. 1235-1238 (1996).
Moser et al., “Effect of microencapsulation on immunogenicity of a bovine herpes virus glycoprotein and inactivated influenza virus in mice”,Vaccine, vol. 15, No. 16, pp. 1767-1772 (1997).
Periwal et al., “Orally Administered Microencapsulated Reovirus Can Bypass Suckled, Neutralizing Material Antibody That Inhibits Active Immunization of Neonates”,Journal of Virology, vol. 71, No. 4, pp. 2844-2850 (Apr. 1997).
Bowersock et al., “Induction of pulmonary immunity in cattle by oral administration of ovalbumin in alginate microspheres”,Immunology Letters, vol. 60, pp. 37-43 (1998).
Cho et al., “Novel mucosal immunization with polysaccharide-protein conjugates entrapped in alginate microspheres”,Journal of Controlled Release, vol. 53, pp. 215-224 (1998).
Jarvinen, “Mucosal Vaccination of Rabbits AgainstPasteurellosisUsingPasteurella multocidaToxin (PT) and a Potassium Thiocyanate Extract ofP. multocida(CN) Encapsulated in Sodium Alginate Microspheres” A Thesis Submitted to the Faculty of Purdue University, May 1997, (released from confidentiality on Oct. 19, 1998).
Moser et al., “Relative Importance of Rotavirus-Specific Effector and Memory B Cells in Protection against Challenge”,Journal of Virology, vol. 72, No. 2, pp. 1108-1114 (1998).
Bowersock et al., “Oral vaccination of animals with antigens encapsulated in alginate microspheres”,Vaccine, vol. 17, pp. 1804-1811 (1999).
MSDS for Alginic Acid, Sodium Salt by Acros Organics U.S.A. of Fair Lawn, New Jersey (Jun. 4, 1999).
Jarvinen et al., “Intranasal Vaccination of New Zealand White Rabbits AgainstPasteurellosis, Using Alginate-EncapsulatedPasteurella multocidaToxin and Potassium Thiocyanate Extract”,Comparative Medicine, vol. 50, No. 3, pp. 263-269 (Jun. 2000).
Kidane et al., “The efficacy of oral vaccination of mice with alginate encapsulated outer membrane proteins ofPasteurella haemolyticaand One-Shot® ”,Vaccine, vol. 19, pp. 2637-2646 (2001).
Mittal et al., “Immunization with DNA, adenovirus or both in biodegradable alginate microspheres: effect of route of inculation on immune response”,Vaccine, vol. 19, pp. 253-263 (2001).
Product Bulletin for Structured Foods with the Algin/Calcium Reaction: Kelco corp. (date unknown).
International Search Report (PCT) dated Feb. 14, 2002, mailed Mar. 22, 2002, for PCT/US01/15235.
Chan et al., “Effect of cellulose derivatives on alginate microspheres prepared by emulsification”,J. Microencapsulation, vol. 14, No. 5, pp. 545-555 (1997).
Lemoine et al., “Preparation and characterization of alginate microspheres containing a model antigen”,International Journal of Pharmaceutics176, pp. 9-19 (1998).
C.J. Gray and J. Dowsett, “Retention of Insulin in Alginate Gel Beads” Biotechnology and Bioengineering, vol. 31, pp. 607-612 (1988).
Jackson, R. et al., “Preparation of 2-5 μm alginate microparticles by emulsification for oral vaccine delivery: Effects of surfactant type, crosslinker, and mixer speed on particle size,” Pharmaceutical Research (New York), vol. 14, No. 11 Suppl., Nov. 1997, pp. S47-S48, XP008000504, Annual Meeting of the American Association of Pharmaceutical Scientists; Boston, Massachusetts, USA; Nov. 2-6, 1997, ISSN: 0724-8741.
Bowersock Terry L.
Guimond Paul
Ju Tzu-Chi R.
Kidane Argaw
Chan Christina
Kim Yunsoo
Pharmacia & Upjohn Company
Pharmacia & Upjohn Company
Wootton Thomas A.
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