Method of utilizing neurotrophins to manipulate reproductive...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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C514S007600, C514S008100, C514S012200

Reexamination Certificate

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11243619

ABSTRACT:
Methods and kits are provided for manipulating and predicting the reproductive capacity of a female subject. The presence of endogenous neurotrophins and addition of exogenous neurotrophins, particularly BDNF, NT-4/5, and NGF, increase the reproductive capacity of a female patient by binding to receptors on the oocytes and stimulating maturation of the oocytes. Administration of antagonists act as a contraceptive because the antagonists prevent the neurotrophins from binding to oocyte receptors. Neurotrophins may also be used to stimulate the maturation of oocyte in vitro.

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