Method of using ribozyme analogs having rigid, non-nucleotidic m

Details Method of using ribozyme analogs having rigid, non-nucleotidic m Method of using ribozyme analogs having rigid, non-nucleotidic m

1995-06-07

1997-10-21

LeGuyader, John L.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435 6, 536 231, 536 245, C07H 2100, C12P 1934, C12Q 168

Patent

active

056795556

ABSTRACT:
Disclosed are ribozyme analogs having the ability to endonucleolytically cleave a sequence of 3' to 5' linked ribonucleotides. The ribozyme analogs include a plurality of 3' to 5' covalently-linked nucleotides, and a rigid molecular linker having at least one non-nucleotidic molecule covalently linked to two of the nucleotides. Also disclosed are methods of preparing and utilizing the ribozyme analogs of the invention, and pharmaceutical formulations and kits containing such ribozyme analogs.

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