Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Tablets – lozenges – or pills
Patent
1992-06-29
1993-12-07
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Tablets, lozenges, or pills
424468, 424469, 424470, 424488, 424474, 424475, 424486, 424499, 424502, 514356, 514824, A61K 922, A61K 930, A61K 31455, A61K 4738
Patent
active
052681815
ABSTRACT:
The invention provides a therapeutic method to treat hyperlipidemia by administering to a human patient a single daily dose of a prolonged release dosage form of niacin, so that nocturnal cholesterol synthesis is effectively suppressed.
REFERENCES:
patent: 3870790 (1975-03-01), Lowey et al.
patent: 4166902 (1979-09-01), Ferruti et al.
patent: 4259314 (1981-03-01), Lowey
patent: 4369172 (1983-01-01), Schor et al.
patent: 4389393 (1983-06-01), Schor et al.
patent: 4432966 (1984-02-01), Zeitova et al.
patent: 4457907 (1984-07-01), Porter
patent: 4568547 (1986-02-01), Herschler
patent: 4680323 (1987-07-01), Lowey
patent: 4704285 (1987-11-01), Alderman et al.
patent: 4708834 (1987-02-01), Cohen et al.
patent: 4749575 (1988-06-01), Rottman
patent: 4752479 (1988-06-01), Briggs
patent: 4756911 (1988-07-01), Drost et al.
patent: 4795642 (1989-01-01), Cohen et al.
patent: 4911917 (1990-03-01), Kuhrts
patent: 4920115 (1990-04-01), Nestler et al.
patent: 4920123 (1990-04-01), Beyer, Jr.
patent: 4950689 (1990-08-01), Yang et al.
patent: 4965252 (1990-10-01), Kuhrts
patent: 5010105 (1991-04-01), Lee
patent: 5011947 (1991-04-01), Catt et al.
patent: 5023245 (1991-06-01), Kuhrts
patent: 5030653 (1991-07-01), Trivedi
patent: 5034528 (1991-07-01), Izydore et al.
patent: 5049696 (1991-09-01), Lee et al.
patent: 5096714 (1991-03-01), Kuhrts
patent: 5110817 (1992-05-01), Beyer et al.
patent: 5110940 (1992-06-01), Sit et al.
patent: 5116610 (1992-05-01), Broaddus
patent: 5126145 (1992-06-01), Evanstad et al.
Methocel as a Binding Agent for Table Production by Wet Granulation, a publication of The Dow Chemical Company, 1985.
Formulating for Controlled Release with Methocel Cellulose Ethers, a publication of The Dow Chemical Company, 1987.
J. D. Alderman et al., "Effect of a Modified, Well-Tolerated Niacin Regimen on Serum Total Cholesterol, Higher Density Lipoprotein Cholesterol and the Cholesterol to High Density Lipoprotein Ratio", Am. J. Cardiology, 64:725 (1989).
Ann. of Intern. Med., "National Education Programs Working Group Report on the Management of Patients with Hypertension and High Blood Cholesterol", 114:224 (1991).
Arch. Intern. Med., "Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults", 148:36 (1988).
I. Bjorkhem et al., "Correlation Between Serum Levels of Some Cholesterol Precursors and Activity of HMG-CoA Reductase in Human Liver", J. Lipid Research, 28:1137 (1987).
D. B. Hunninghake, editor, Issues in Cholesterol Management: Reappraisal of Niacin, Upsher-Smith Laboratories, Inc. (publisher) (1990).
T. A. Miettinen, "Election of Changes in Human Cholesterol Metabolism", Ann. Clin. Res., 2:300 (1970).
T. A. Miettinen, "Diurnal Variation of Cholesterol Precursors Squalene and Methyl Sterols in Human Plasma Lipoproteins", J. Lipid Res., 23:466 (1982).
T. A. Miettinen, "Cholesterol Precursors and Their Diurnal Rhythm in Lipoproteins of Patients with Jejuno-Ileal Bypass and Ileal Disfunction", Metabolism, 34:425 (1985).
M. J. Robinson, "Coating of Pharmaceutical Dosage Forms", Remington's Pharmaceutical Sciences, A. Osol, ed., Mack Publishing Co., Easton, Pa., (16th edition) (1980) at pp. 1585-1593.
J. C. Rosa, Circulation, "The Cholesteral Facts", 81:1721 (1990).
S. Yusek et al., "Overview of Results of Randomized Clinical Trials in Heart Disease", JAMA, 260:2259 (1988).
H. G. Zimmerman et al., "Drugs Used in Cardiovascular Disease", Hepatotoxicity, Appleton-Century-Crofts, New York, N.Y. (1978) at pp. 510-512.
Evenstad Kenneth L.
O'Neill Victoria A.
Page Thurman K.
Spear James M.
Upsher-Smith Laboratories, Inc.
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