Method of using N-arylheteroarylalkyl 1-heteroaryl-imidazol-2-on

Details Method of using N-arylheteroarylalkyl 1-heteroaryl-imidazol-2-on Method of using N-arylheteroarylalkyl 1-heteroaryl-imidazol-2-on

1992-10-13

1995-09-19

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514341, A61K 3144

Patent

active

054515920

ABSTRACT:
A class of N-arylheteroarylalkyl 1-heteroaryl-imidazol-2-one compounds is described for use in treatment of glaucoma disorder. Compounds of particular interest are angiotensin II antagonists of the formula ##STR1## wherein A is selected from ##STR2## wherein R.sup.1 is selected from hydrido and alkyl; wherein each of R.sup.2, R.sup.3 and R.sup.4 is independently selected from hydrido, alkyl, alkoxy, halo, hydroxy, carboxyl, alkoxycarbonyl, formyl and acetyl; wherein R.sup.5 is hydrido; wherein R.sup.6 is alkyl; wherein R.sup.7 is an acidic group selected from COOH and ##STR3## or a stereoisomer or a tautomer thereof or a pharmaceutically-acceptable salt thereof.

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