Method of using megapoietin for prolonging the survival & viabil

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

424 851, 514 2, 514 8, 514 12, 514885, A61K 3819, C07K 1452

Patent

active

055716865

ABSTRACT:
New therapies for treating blood platelet disorders based on the megapoietin gene and protein are described. Additional utilities for megapoietin such as increasing the storage life of platelet and whole blood preparations, a means for selectively targeting therapeutic or imaging agents to arterial clots, and a means for selectively stimulating platelet production from megakaryocytes in vivo and in vitro (e.g., as a source of platelets for transplantation) and to stimulate stem cell growth are also described.

REFERENCES:
patent: 5260417 (1993-11-01), Grant et al.
Mazun et al. (1981), Journal of Clinical Investigation, vol. 68, pp. 733-741.
Bartley, T. D. et al. "Identification and Cloning of a Megakaryocyte Growth and Development Factor That Is a Ligand for the Cytokine Receptor Mpl" Cell 77: 1117-1124 (1 Jul. 1994).
de Sauvage, F. et al. "Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand" Nature 369: 533-538 (16 Jun. 1994).
Kaushansky, K. et al. "Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin" Nature 369: 568-571 (16 Jun. 1994).
Kuter, D. J. and R. D. Rosenberg "Appearance of a Megakaryocyte Growth-Promoting Activity, Megapoietin, During Acute Thrombocytopenia in the Rabbit" Blood 84(5): 1454-1472 (1 Sep. 1994).
Kuter, D. J. et al. "The purification of megapoietin: A physiological regulator of megakaryocyte growth and platelet production" Proc. Natl. Acad. Sci. USA 91: 11104-11108 (Nov. 1994).
Lok, S. et al. "Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo" Nature 369: 565-568 (16 Jun. 1994).
Wendling, F. et al. "c-Mpl ligand is a humoral regulator of megakaryocytopoiesis" Nature 369: 571-574 (16 Jun. 1994).
Radek C. Skoda, David C. Seldin, Ming-Ko Chiang, Catherine L. Peichel, Thomas F. Vogt and Philip Leder, "Murine c-mpl: a member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal", The EMBO Journal, vol. 12, No. 7, pp. 2645-2653 (1993).
Nassia Methia, Fawzia Louache, William Vainchenker and Francoise Wendling, "Oligodeoxynucleotides Antisense to the Proto-oncogene c-mpl Specifically Inhibit In Vitro Megakaryocytopoiesis", Blood, vol. 82, No. 5, pp. 1395-1401 (Sep. 1, 1993).
Ronald J. Hill, Jack Levin and Francine C. Levin, "Correlation of in vitro and in vivo Biological Activities During the Partial Purification of Thrombopoietin", Experimental Hematology, vol. 20, pp. 354-360 (1992).
Isabelle Vigon, Jean-Paul Mornon, Laurence Cocault, Marie-Therese Mitjavila, Pierre Tambourin, Sylvie Gisselbrecht and Michele Souyri, "Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: Identification of a member of the hematopoietic growth factor receptor superfamily", Proc. Natl. Acad. Sci. USA, vol. 89, pp. 5640-5644 (Jun. 1992).
David J. Kuter, Dianne M. Gminski and Robert D. Rosenberg, "Transforming Growth Factor .beta. Inhibits Megakaryoctye Growth and Endomitosis", Blood, vol. 79, No. 3, pp. 619-626 (Feb. 1, 1992).
Neil Williams, "Is Thrombopoietin Interleukin 6?", Experimental Hematology, vol. 19, pp. 714-718 (1991).
Michele Souyri, Isabelle Vigon, Jean-Francois Penciolelli, Jean-Michel Heard, Pierre Tambourin and Francoise Wendling, "A Putative Truncated Cytokine Receptor Gene Transduced by the Myeloproliferative Leukemia Virus Immortalizes Hematopoietic Progenitors", Cell, vol. 63, pp. 1137-1147 (Dec. 21, 1990).
David J. Kuter and Robert D. Rosenberg, "Regulation of Megakaryocyte Ploidy In Vivo in the Rat", Blood, vol. 75, No. 1, pp. 74-81 (Jan. 1, 1990).
Julio E. Celis, Gitte P. Ratz, Peder Madsen, Borbala Gesser, Jette B. Lauridsen, Sianette Kwee, Hanne Holm Rasmussen, Henrik V. Nielsen, Dorthe Cruger, Bodil Basse, Henrik Leffers, Bent Honore, Olaf Moller, Ariana Celis, Joel Vandekerckhove, Guy Bauw, Jozef van Damme, Magda Puype and Marc Van den Bulcke,"Comprehensive, human cellular protein databases and their implication for the study of genome organization and function", FEBS LETTERS, vol. 244, No. 2, pp. 247-254 (Feb. 1989).
David J. Kuter, Sheryl M. Greenbeg and Robet D. Rosenberg, "Analysis of Megakaryocyte Ploidy in Rat Bone Marrow Cultures", Blood, vol. 74, No. 6, pp. 1952-1962 (Nov. 1, 1989).
T. P. McDonald, "Thrombopoietin: Its Biology, Purification and Characterization", Experimental Hematology, vol. 16, pp. 201-205 (1988).
Guy Tayrien and Robert D. Rosenberg, "Purification and Properties of a Megakaryocyte Stimulatory Factor Present Both in the Serum-free Conditioned Medium of Human Embryonic Kidney Cells and in Thrombocytopenic Plasma", The Journal of Biological Chemistry, vol. 262, No. 7, pp. 3262-3268 (1987).
Sheryl M. Greenberg, David J. Kuter and Robert D. Rosenberg, "In Vitro Stimulation of Magakaryocyte Maturation by Megakaryocyte Stimulatory Factor", The Journal of Biological Chemistry, vol. 262, No. 7, pp. 3269-3277 (1987).
Bertram Spector, "In vivo Transfer of a Thrombopoietic Factor", P.S.E.B.M., vol. 108 (1961).
International Search Report (Form PCT/ISA/220) for PCT/US95/04617 mailed on Jul. 12, 1995.
McDonald et al., "A Four-Step Procedure for the Purification of Thrombopoietin", Experimental Hematology, vol. 17, pp. 865-871 (1989).
Vannucchi et al., "Partial Purification and Biochemical Characterization of Human Plasma Thrombopoietin", Leukemia, vol. 2, No. 4, pp. 236-239 (Apr. 1988).
Zeigler et al., "In Vitro Megakaryocytopoietic and Thrombopoietic Activity of c-mpl Ligand (TPO) on Purified Murine Hematopoietic Stem Cells", Blood, vol. 84, No. 12, pp. 4045-4052 (Dec. 1994).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method of using megapoietin for prolonging the survival & viabil does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of using megapoietin for prolonging the survival & viabil, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of using megapoietin for prolonging the survival & viabil will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2014311

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.