Method of using magnetic particles for isolating, collecting and

Details Method of using magnetic particles for isolating, collecting and Method of using magnetic particles for isolating, collecting and

1989-02-02

1992-10-27

Kepplinger, Esther L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

424 9, 435971, 436526, 436811, G01N 33569, G01N 33553

Patent

active

051588714

ABSTRACT:
An in vivo method for preparing, inserting, isolating, collecting and assaying diagnostic ligates present in body fluids. Magnetically responsive particles with attached ligands specific for a particular ligate are introduced into the body fluid. Bonding between the ligand and ligate results in particle/ligand/ligate complexes. The complexes are removed by the application of a magnetic field and the complexes are permitted to cluster. The clusters are then quantitated to determine the concentration of the ligate in the body fluid. Associated materials and devices useful in the practice of this method are also provided.

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Mathur et al., Fertility and Sterility, vol. 46, No. 3, pp. 484-488, (1986).
Biological Abstacts vol. 83 (1987), Abstract No. 118315, Ohmori, Y., et al.
Biological Abstracts vol. 84 (1987), Abstract No. 109258, Heath et al.

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