Method of using LDH as a predictor of the adult respiratory dist

Details Method of using LDH as a predictor of the adult respiratory dist Method of using LDH as a predictor of the adult respiratory dist

1994-11-30

1997-06-17

Gitomer, Ralph

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving oxidoreductase

435 13, 435 27, C12Q 132, C12Q 130

Patent

active

056396295

ABSTRACT:
At the initial diagnosis of sepsis (6-24 h before the development of ARDS), serum lactate dehydrogenase (LDH) activity level is increased in septic patients who subsequently develop ARDS compared to healthy patients and septic patients who do not develop ARDS. A method is disclosed for predicting the occurrence of ARDS in a septic patient from the patient's serum level of LDH activity, which method facilitates identification of subsets of patients destined to develop ARDS and allows prospective treatment of such septic patients.

REFERENCES:
patent: 5389522 (1995-02-01), Repine
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Dwenger, A., Nonspecific Immune System . . . Adult Respiration Distress Syndrome, Springer Verlag, Berlin, 1991 pp. 91-127.
Montaner J., Multisystem Organ Failure Predicts . . . Chest 102 (6) Dec 1992 pp. 1823-1828 (C42).
Leff J., Serum Antioxidants As Predictors Of Adult . . . Lancet 341 Mar. 27, 1993 pp. 777-780.
Wang Y., Protective Effect Of Heat Shock Response On Oleic Acid Induced Lung Injury In Rats, Hunan Yike Daxue Xuebao 17(4) 1992 pp. 337-339.

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