Drug – bio-affecting and body treating compositions – Lymphokine – Interleukin
Reexamination Certificate
2008-03-06
2010-06-01
Bunner, Bridget E (Department: 1647)
Drug, bio-affecting and body treating compositions
Lymphokine
Interleukin
C514S012200, C514S894000
Reexamination Certificate
active
07727518
ABSTRACT:
Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.
REFERENCES:
patent: 4766106 (1988-08-01), Katre et al.
patent: 4853332 (1989-08-01), Mark et al.
patent: 5206344 (1993-04-01), Katre et al.
patent: 6927040 (2005-08-01), Sheppard et al.
patent: 7038032 (2006-05-01), Sheppard et al.
patent: 7135170 (2006-11-01), Klucher et al.
patent: 7157559 (2007-01-01), Brady et al.
patent: 7241870 (2007-07-01), Sheppard et al.
patent: 7252969 (2007-08-01), Sheppard et al.
patent: 7253261 (2007-08-01), Sheppard et al.
patent: 7351689 (2008-04-01), Doyle et al.
patent: 2002/0110855 (2002-08-01), Sheppard et al.
patent: 2004/0029228 (2004-02-01), Presnell et al.
patent: 2007/0020227 (2007-01-01), Sheppard et al.
patent: 2007/0041936 (2007-02-01), Brady et al.
patent: 2007/0041975 (2007-02-01), Brady et al.
patent: 2007/0042468 (2007-02-01), Sheppard et al.
patent: 2007/0042469 (2007-02-01), Brady et al.
patent: 2007/0042470 (2007-02-01), Brady et al.
patent: 2007/0042471 (2007-02-01), Brady et al.
patent: 2007/0048274 (2007-03-01), Brady et al.
patent: 2007/0048275 (2007-03-01), Brady et al.
patent: 2007/0048276 (2007-03-01), Brady et al.
patent: 2007/0048277 (2007-03-01), Brady et al.
patent: 2007/0048841 (2007-03-01), Sheppard et al.
patent: 2007/0048843 (2007-03-01), Brady et al.
patent: 2007/0048844 (2007-03-01), Brady et al.
patent: 2007/0049737 (2007-03-01), Brady et al.
patent: 2007/0053875 (2007-03-01), Brady et al.
patent: 2007/0053933 (2007-03-01), Sheppard et al.
patent: 2007/0054374 (2007-03-01), Brady et al.
patent: 2007/0054375 (2007-03-01), Brady et al.
patent: 2007/0054376 (2007-03-01), Brady et al.
patent: 2007/0054377 (2007-03-01), Brady et al.
patent: 2007/0055051 (2007-03-01), Brady et al.
patent: 2007/0055052 (2007-03-01), Brady et al.
patent: 2007/0055053 (2007-03-01), Brady et al.
patent: 2007/0055054 (2007-03-01), Brady et al.
patent: 2007/0059313 (2007-03-01), Brady et al.
patent: 2007/0059804 (2007-03-01), Brady et al.
patent: 2007/0065406 (2007-03-01), Brady et al.
patent: 2007/0066810 (2007-03-01), Brady et al.
patent: 2007/0073044 (2007-03-01), Brady et al.
patent: 2007/0117967 (2007-05-01), Brady et al.
patent: 2007/0128205 (2007-06-01), Sheppard et al.
patent: 2007/0129538 (2007-06-01), Sheppard et al.
patent: 2007/0154446 (2007-07-01), Brady et al.
patent: 2007/0166282 (2007-07-01), Brady et al.
patent: 2007/0172923 (2007-07-01), Brady et al.
patent: 2007/0264684 (2007-11-01), Sheppard et al.
patent: 2008/0032334 (2008-02-01), Sheppard et al.
patent: 2008/0075693 (2008-03-01), Klucher et al.
patent: 2008/0081786 (2008-04-01), Sheppard et al.
patent: 2008/0096252 (2008-04-01), Zamost et al.
patent: 2008/0102490 (2008-05-01), Sheppard et al.
patent: 2008/0124299 (2008-05-01), Klucher et al.
patent: 2008/0132680 (2008-06-01), Sheppard et al.
patent: 2008/0167244 (2008-07-01), Doyle et al.
patent: 2009/0069274 (2009-03-01), Sheppard et al.
patent: 0 032 134 (1981-07-01), None
patent: 02/02627 (2002-01-01), None
patent: 02/20569 (2002-03-01), None
patent: 02/086087 (2002-10-01), None
patent: 02/092762 (2002-11-01), None
patent: 03/066002 (2003-08-01), None
patent: 03/089603 (2003-10-01), None
patent: 2004/037995 (2004-05-01), None
patent: 2005/023862 (2005-03-01), None
patent: 2005/097165 (2005-10-01), None
AASLD, Oct. 2009, pp. 1-5.
Doyle et al, Hepatology, 2005, vol. 44, pp. 896-906.
Sheppard et al., U.S. Appl. No. 11/971,624, filed Jan. 9, 2008.
Sheppard et al., U.S. Appl. No. 12/353,454, filed Jan. 12, 2009.
Kotenko et al., “IFN-λs mediate antiviral protection through a distinct class II cytokine receptor complex,”Nature Immunology4(1):69-77, 2003.
Sheppard et al., “IL-28, II-29 and their class II cytokine receptor IL-28R,”Nature Immunology4(1):63-68, 2003.
Langer et al., “The Class II cytokine receptor (CRF2) family: overview and patterns of receptor-ligand interactions,”Cytokine and Growth Factor Reviews15:33-48, 2004.
Donnelly et al., “The expanded family of class II cytokines that share the IL-10 receptor-2 (IL-10R2) chain,”J. Leukocyte Biol.76:314-321, 2004.
Dumoutier et al., “Role of the Interleukin (IL)-28 Receptor Tyrosine Residues for Antiviral and Antiproliferative Activity of IL-29/Interferon-λ1,”J. Biochem.279(31):32269-32274, 2004.
University Calif. Santa Cruz Genome Browser—Chromosome 19, Apr. 20, 2001.
University Calif. Santa Cruz Genome Browser Database—Aug. 6, 2001, Accession No. C19001210.
University Calif. Santa Cruz Genome Browser Database—Aug. 6, 2001, Accession No. C19001212.
University Calif. Santa Cruz Genome Browser Database—Aug. 6, 2001, Accession No. C19001213.
University Calif. Santa Cruz Genome Browser Database—Dec. 22, 2001, Accession No. C19001260.
University Calif. Santa Cruz Genome Browser Database—Dec. 22, 2001, Accession No. C19001256.
University Calif. Santa Cruz Genome Browser Database—Dec. 22, 2001, Accession No. C19001257.
Ensembl Contig. View Sanger Institute—Apr. 19, 2001, Accession No. AC011445.
Ensembl Contig. View Sanger Institute—Apr. 18, 2000, Accession No. AC018477.
Adams et al., “3,400 expressed sequence tags identify diversity of transcripts from human brain,”Nat. Genet.4:256-267, 1993.
GenBank Submission XP-002202436, Oct. 12, 2000.
GenBank Submission XP-002202437, Dec. 12, 1999.
Kindsvogel et al., “Novel Interferon-Like Cytokines not Recognized by the Type I Interferon Receptor,”J. Interferon Cytokine Res.22(1):S-48, 2002.
Adams et al., Accession No. T07139, 1993.
DOE Joint Genome Institute Stanford Human Genome Center, Accession No. AC011445, 1999.
Muzney et al., Accession No. AC007458, 1999.
University of California Santa Cruz database using Softberry, Inc. gene prediction software, Accession No. C19001084, 2001.
Scott et al., “The Pendred syndrome gene encodes a chloride-iodide transport protein,”Nature Genetics, 21:440-443, 1999.
Korba et al., “A cell culture assay for compounds which inhibit hepatitis B virus replication,”Antiviral Research15:217-228, 1991.
Brack et al., “Molecular analysis of the human interferon-α gene family,”Gene15:379-394, 1981.
Francis et al., “PEGylation of cytokines and other therapeutic proteins and peptides: the importance of biological optimization of coupling techniques,”International Journal of Hematology, 68(1):1-18, 1998.
Rajarathnam et al., “Disulfide Bridges in Interleukin-8 Probed Using Non-Natural Disulfide Analogues: dissociation of Roles in Structure from Function,”Biochemistry38:7653-7658, 1999.
Luxon et al., “Pegylated Interferons for the Treatment of Chronic Hepatitis C Infection,”Clinical Therapeutics24(9):13631383, 2002.
Kozlowski et al., “Improvements in protein OEGylation: pegylated interferons for treatment of hepatitis C,”Journal of Controlled Release72:217-224, 2001.
Goodson et al., “Site-Directed Pegylation of Recombinant Interleukin-2 at its Glycosylation Site,”Bio/Technology8(4):343-346, 1990.
Pettit et al., “Structure-Function Studies of Interleukin 15 using Site-specific Mutagenesis, Polyethylene Glycol Conjugation, and Homology Modeling,”J. Biochem272(4):2312-2318, 1997.
Burge et al., “Prediction of Complete Gene Structures in Human Genomic DNA,”J. Mod. Biol.268:78-94, 1997.
Vilcek, “Novel interferons,” Nature Immunology 4(1):8-9, 2003.
Sheppard et al., U.S. Appl. No. 11/873,272, filed Oct. 16, 2007.
University Calif. Santa Cruz Genome Browser—Chromosome 19, Apr. 20, 2001.
Kozlowski et al., Bio. Drug., 15(7): 419-429, 2001.
Wells, Biochemistry, 29(37): 8509-8517, 1990.
Brady Lowell J.
Bukowski Thomas R.
Chan Chung
Dong Dennis L.
Klucher Kevin M.
Bunner Bridget E
Hamud Fozia M
Walsh Brian J.
ZymoGenetics, LLC
LandOfFree
Method of using IL-29 cysteine mutant to treat hepatitis C... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of using IL-29 cysteine mutant to treat hepatitis C..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of using IL-29 cysteine mutant to treat hepatitis C... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4236664