Nanotechnology – Nanostructure – Nanoparticle
Reexamination Certificate
2009-09-08
2011-10-11
Angell, J. E. (Department: 1635)
Nanotechnology
Nanostructure
Nanoparticle
C514S04400A
Reexamination Certificate
active
08035016
ABSTRACT:
Provided are methods and compositions for inhibiting expression of one or more target genes. The compositions contain RNA polynucleotides that can inhibit expression of a target gene via RNA interference (RNAi) electrostatically complexed with surface functionalized gold nanorods (GNRs). The RNA polynucleotides are not covalently bound to the surface functionalized GNRs. The method involves inhibiting expression of a target gene in an individual. The method is performed by administering to the individual an effective amount of a composition containing surface functionalized GNRs electrostatically complexed with RNA polynucleotides, such as siRNA, that can inhibit expression of the target gene via RNAi. The siRNA is not covalently bound to the surface functionalized GNRs.
REFERENCES:
patent: 2006/0058255 (2006-03-01), Chen et al.
patent: 2008/0199531 (2008-08-01), Salem et al.
Roy et al.; Non-viral gene transfection nanoparticles: Function and applications in brain; Nanomedicine, Jun. 2008, vol. 4, No. 2; pp. 89-97.
Niidome et al.; Preparation of primary amine-modified gold nanoparticles and their transfection ability into cultivated cells; Chem. Commun., Sep. 7, 2004, vol. 17; pp. 1978-1979.
Ding et al.; Gold Nanorods Coated with Multilayer Polyelectrolyte as Contrast Agents for Multimodal Imaging; J. Phys. Chem., 2007, vol. 111, No. 34; pp. 12552-12557.
Bergey Earl J.
Bonoiu Adela
Mahajan Supriya
Prasad Paras N.
Roy Indrajit
Angell J. E.
Hodgson & Russ LLP
The Research Foundation of State University of New York
LandOfFree
Method of using gold nanorods-siRNA complexes does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of using gold nanorods-siRNA complexes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of using gold nanorods-siRNA complexes will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4287060