Electricity: measuring and testing – Particle precession resonance – Using a nuclear resonance spectrometer system
Reexamination Certificate
2011-02-01
2011-02-01
Borin, Michael (Department: 1631)
Electricity: measuring and testing
Particle precession resonance
Using a nuclear resonance spectrometer system
C324S310000
Reexamination Certificate
active
07880468
ABSTRACT:
The present invention presents a new approach to rapidly obtaining precise high-dimensional NMR spectral information, named “GFT NMR spectroscopy”, which is based on the phase sensitive joint sampling of the indirect dimensions spanning a subspace of a conventional NMR experiment. The phase-sensitive joint sampling of several indirect dimensions of a high-dimensional NMR experiment leads to largely reduced minimum measurement times when compared to FT NMR. This allows one to avoid the “sampling limited” data collection regime. Concomitantly, the analysis of the resulting chemical shift multiplets, which are edited by the G-matrix transformation, yields increased precision for the measurement of the chemical shifts. Additionally, methods of conducting specific GFT NMR experiments as well as methods of conducting a combination of GFT NMR experiments for rapidly obtaining precise chemical shift assignment and determining the structure of proteins or other molecules are disclosed.
REFERENCES:
patent: 4480228 (1984-10-01), Bottomley
patent: 4506223 (1985-03-01), Bottomley et al.
patent: 4509015 (1985-04-01), Ordidge et al.
patent: 4682106 (1987-07-01), Vatis et al.
patent: 4703270 (1987-10-01), Hall et al.
patent: 5081417 (1992-01-01), Bovée et al.
patent: 5657758 (1997-08-01), Posse et al.
patent: 5709208 (1998-01-01), Posse et al.
patent: 5879299 (1999-03-01), Posse et al.
patent: 6873153 (2005-03-01), Frydman
patent: 2003/0102866 (2003-06-01), Katscher et al.
patent: 2004/0095140 (2004-05-01), Szyperski et al.
Szyperski et al., “Reduced Dimensionality in Triple-Resonance NMR Experiments,”J. Am. Chem. Soc., 115:9307-9308 (1993).
Brutscher et al., “Determination of an Initial Set of NOE-Derived Distance Constraints for the Structure Determination of15N/13C-Labeled Proteins,”J. Magn. Reson. Ser. B109:238-242 (1995).
Szyperski et al., “Useful Information from Axial Peak Magnetization in Projected NMR Experiments,”J. Am. Chem. Soc., 118:8146-8147 (1996).
Lohr et al., “A New Triple-Resonance Experiment for the Sequential Assignment of Backbone Resonances in Proteins,”J. Biomol. NMR, 6:189-197 (1995).
Szyperski et al., “Reduced-Dimensionality NMR Spectroscopy for High-Throughput Protein Resonance Assignment,”Proc. Natl. Acad. Sci. USA, 99:8009-8014 (2002).
Ding et al., “Novel 2D Triple-Resonance NMR Experiments for Sequential Resonance Assignments of Proteins,”J. Magn. Reson., 156:262-268 (2002).
Koźmiński et al., “Multiple Quadrature Detection in Reduced Dimensionality Experiments,”J. Biomol. NMR, 26:157-166 (2003).
Kim et al., “GFT NMR, a New Approach to Rapidly Obtain Precise High-Dimensional NMR Spectral Information,”J. Am. Chem. Soc., 125:1385-1393 (2003).
Atreya Hanudatta S.
Kim Seho
Szyperski Thomas A.
Borin Michael
Nixon & Peabody LLP
The Research Foundation of State University of New York
LandOfFree
Method of using G-matrix fourier transformation nuclear... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of using G-matrix fourier transformation nuclear..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of using G-matrix fourier transformation nuclear... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2649463