Method of using cyclooxygenase-2 inhibitors in the treatment and

Details Method of using cyclooxygenase-2 inhibitors in the treatment and Method of using cyclooxygenase-2 inhibitors in the treatment and

1997-10-14

1999-10-26

Krass, Frederick

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514210, 514247, 514252, 514341, 514365, 514372, 514374, 514378, 514399, 514400, 514403, 514407, 514602, 514603, 514604, 514605, 514709, A01N 4356, A61K 31415

Patent

active

059729864

ABSTRACT:
This invention relates to the use of cyclooxygenase-2 inhibitors or derivatives thereof in preventing and treating neoplasia. In particular, the invention describes the method of preventing and treating epithelial cell neoplasia in a subject, said method comprising treating the subject with a therapeutically-effective amount of a compound of Formula I. ##STR1## wherein A, R.sup.2 and R.sup.3 are as described in the specification.

REFERENCES:
patent: 5466823 (1995-11-01), Talley et al.
B.S. Teicher et al, "Cyclooxygenase and Lipoxygenase Inhibitors as Modulators of Cancer Therapies", Cancer Chemotherapy and Pharmacology, vol. 33, pp.515-522, Dec. 1994.
Huang et al., "Cyclooxygenase and 5-Lipoxygenase Inhibitors for the Prevention and Treatment of Cancer", Expert Opinion on Investigational Drugs, vol. 4, No. 3, pp. 243-249, Aug. 1995.

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