Method of using autologous fibroblasts to promote healing of...

Details Method of using autologous fibroblasts to promote healing of... Method of using autologous fibroblasts to promote healing of...

2000-05-26

2010-12-07

Azpuru, Carlos A (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

Reexamination Certificate

active

07846465

ABSTRACT:
The invention provides a method or promoting healing of a wound, e.g., an epithelial wound, in an animal. The method involves administering cultured autologous fibroblasts to the wound.

REFERENCES:
patent: 5866167 (1999-02-01), Van Bossuyt
patent: 19716098 (1998-10-01), None
patent: WO 99/60951 (1999-12-01), None
Harris et al., “Use of Hyaluronic acid and cultured autologous keratinocytes and fibroblasts in extensive burns”, Research Letters, Lancet, 353 (9146) pp. 35-36 (1999).
Hansbrough et al., “Burn Wound Closure with Cultured Autologous Keratinocytes and Fibroblasts Attached to a Collagen-Glycosaminoglycan Substrate”, JAMA, 262(15):2125-2130 (1989).
Van Zuijlen et al., “Practical sources for autologous fibroblasts to prepare a bioengineered dermal equivalent”, Burns, 24 (7): 687 (1998).
Mansbridge, “Skin substitutes to enhance wound healing”, Expert Opinion on Investigational Drugs, 7(5):803-809 (1998).
Kon et al., “Transformation of fibroblasts into endothelial cells during angiogenesis”, Cell and Tissue Research 278(3):625-628 (1994).

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