Method of using a TAQ DNA polymerase without 5'-3'-exonuclease a

Details Method of using a TAQ DNA polymerase without 5'-3'-exonuclease a Method of using a TAQ DNA polymerase without 5'-3'-exonuclease a

1989-08-03

1992-04-28

Wax, Robert A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 91, 435280, 435810, 436501, 436 94, 935 77, 935 78, C12Q 168, C12Q 1934, G01N 33566, G01N 3348

Patent

active

051088924

ABSTRACT:
The present invention is directed to a modified Taq DNA polymerase and methods for its use.

REFERENCES:
patent: 4889818 (1989-12-01), Gelfand et al.
Bethesda Research Laboratories Life Technologies, Inc., promotional literature entitled "Dideoxy Sequencing Protocol for using BRL's High-Purity Test DNA Polymerase."
Bethesda Research Laboratories Lift Technologies, Inc., promotional literature entitled "High Purity Taq DNA Polymerase for Dideoxy Sequencing."
Bethesda Research Laboratories Life Technologies, Inc., "Highly Purified DNA Polymerase from Thermus aquaticus," D'Alession, J. M., et al., Focus 11:2, pp. 30-31.
Chien et al., 1976, Journal of Bacteriology, vol. 127, No. 3, pp. 1550-1557.
Freifelder, David, 1976, Physical Biochemistry, W. H. Freeman and Company, pp. 217-220.
Heiner, C. et al., 1988, Applied Biosystems, Inc. DNA Sequencer Model 370 User Bulletin-Taqu Polymerase: Increased Enzyme Versatility in DNA Sequencing.
Higuchi, R. et al., 1988, Nucleic Acids Research, vol. 16, No. 15, pp. 7351-7367.
Hong, G. F., 1982, Bioscience Reports, vol. 2, pp. 907-912.
Innis et al., 1988, Proc. Natl. Acad. Sci. USA, vol. 85, pp. 9436-9440.
Kaledin et al., 1980, translated from Biokhimiya, vol. 45, No. 4, pp. 644-651.
Labeit, S. 1987, Methods in Enzymology, vol. 155, pp. 166-177.
Lawyer, F. C. et al., 1988, J. Biol. Chem., vol. 264, No. 11, pp. 6427-6437.
Lo, Y-M. D. et al., 1988, Nucleic Acids Research, vol. 16, No. 17, p. 8719.
McGraw, R. A., 1984, Anal. Biochem., vol. 143, pp. 298-303.
Promega Notes No. 16 (Nov. 1988) describes the TaqTrack.TM. DNA Sequencing System.

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