Method of using a secretable glial mitogenic factor to induce ac

Details Method of using a secretable glial mitogenic factor to induce ac Method of using a secretable glial mitogenic factor to induce ac

1995-06-06

1997-02-11

Walsh, Stephen G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 530350, 435 691, A61K 3818

Patent

active

056020961

ABSTRACT:
Disclosed is the characterization and purification of DNA encoding numerous polypeptides useful for the stimulation of glial cell (particularly, Schwann cell mitogenesis and treating glial cell tumors. Also disclosed are DNA sequences encoding novel polypeptides which may have use in stimulating glial cell mitogenesis and treating glial cell tumors. Methods for the synthesis, purification and testing of both known and novel polypeptides for their use as both therapeutic and diagnostic aids in the treatment of diseases involving glial cells are also provided. Methods are also provided for the use of these polypeptides for the preparation of antibody probes useful for both diagnostic and therapeutic use in diseases involving glial cells. The present invention is specifically directed to a method of using a secretable glial growth factor to induce acetycholine receptor synthesis.

REFERENCES:
patent: 5237056 (1993-08-01), Fischbach
Uedin et al., J. Cell Biology, vol. 103, pp. 493-507, 1986.

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