Method of using 1,5-anhydrohexitol nucleoside analogues to treat

Details Method of using 1,5-anhydrohexitol nucleoside analogues to treat Method of using 1,5-anhydrohexitol nucleoside analogues to treat

1995-06-07

1997-09-16

Kunz, Gary L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 45, 514 48, 514 49, 514 52, A61K 3170, C07H 1904

Patent

active

056681135

ABSTRACT:
It has been found that 1,5-anhydrohexitol nucleoside analogues, wherein a 4-substituted-2,3,4-trideoxy-1,5-anhydrohexitol is coupled via its 2-position to the heterocyclic ring of a pyrimidine or purine base, exhibit remarkable anti-viral properties against herpes viruses, pox viruses and related viruses.
The new nucleoside analogues are represented by the general formula I ##STR1## wherein B is a heterocyclic ring derived from a pyrimidine or purine base, X represents H, N.sub.3, F, Cl, Br, I, amino, --NHR.sup.2, --N(R.sup.2).sub.2, --OR.sup.2, --SR.sup.2 or CN, R.sup.1 and R.sup.2 are the same or different and hydrogen, alkyl, acyl or phosphate groups are represented, or wherein X is hydrogen and a double bond is situated between the 3- and 4- position of the 1,5-anhydrohexitol ring.
Pharmaceutically acceptable salts and esters thereof are included.

REFERENCES:
L. Dee Nord et al., "Synthesis, Structure, and Biological Activity of Certain 2-Deoxy-.beta.-D-ribohexopyranosyl Nucleosides and Nucleotides", Journal of Medicinal Chemistry, vol. 30, No. 6 (1987), pp. 1044-1054.
Poul Hansen et al., "Synthesis of 3'-Azido-2',3'-dideoxy-.beta.-D-arabino-hexopyranosyl Nucleosides", Liebigs Annalen der Chemie, vol. 1990, No. 11 (1990), pp. 1079-1082.

Affiliated with

Also associated with

Rating

Method of using 1,5-anhydrohexitol nucleoside analogues to treat does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of using 1,5-anhydrohexitol nucleoside analogues to treat, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of using 1,5-anhydrohexitol nucleoside analogues to treat will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-218233