Method of use of polymers containing cross-linked azo bonds for

Details Method of use of polymers containing cross-linked azo bonds for Method of use of polymers containing cross-linked azo bonds for

1984-07-18

1987-05-05

Higel, Floyd D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

534573, 534585, 534588, 534593, 534599, 534843, 534887, 514 2, 514 54, 514 56, 514150, 514151, 514568, 514772, 514778, 514960, 514961, 514962, 514963, 514964, A61K 4700, C07C10700

Patent

active

046633081

ABSTRACT:
Polymers from ethylenically unsaturated monomers, cross-linked by a substituted or unsubstituted divinylazobenzene are useful as carriers or capsules for medicaments, which are degraded by the enzymes of the upper gastrointestinal tract or which must be transferred intact past the upper gastrointestinal tract, to deliver the medicament to the large intestine.
Polymers containing monomeric units of the formula

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patent: 4190716 (1980-02-01), Parkinson et al.
patent: 4298595 (1981-11-01), Parkinson et al.
Peppercorn, Mark A. and Peter Goldman: The Role of Intestinal Bacteria in the Metabolism of Salicylazosulfapyridine, J. Pharmacol. Exp. Ther. 181: 555-562, 1972.
Saffran, M.: Oral Administration of Peptides, Endocrinologia Experimentalis 16, 327-333, 1982.
Saffran, M., Franco-Saenz, R., Kong, A., Papahadjopoulos, D. & Szoka, F. (1979) A Model for the Study of the Oral Administration of Peptide Hormones, Can. J. Biochem. 57, 548-553.

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