Method of use of peptide antagonists of zonulin to prevent...

Details Method of use of peptide antagonists of zonulin to prevent... Method of use of peptide antagonists of zonulin to prevent...

2006-04-11

2006-04-11

Weber, Jon (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S013800, C514S014800, C514S015800, C514S016700, C514S866000, C530S324000, C530S326000, C530S327000, C530S328000, C530S350000, C530S844000

Reexamination Certificate

active

07026294

ABSTRACT:
A method for prevention of delaying the onset of diabetes using peptide antagonists of zonulin, is disclosed.

REFERENCES:
patent: 5665389 (1997-09-01), Fasano
patent: 5945510 (1999-08-01), Fasano
patent: WO 96/37196 (1996-11-01), None
patent: WO 00/07609 (2000-02-01), None
Watts et al., PNAS (USA), vol. 102, No. 8, pp. 2916-2921, Feb. 22, 2005.
Meddings et al,American Physiological Society, pp. G951-G957 (1999).
Watts et al,Gastroenterology, 118(4, Supp.2, Part 1 of 2): 101stAnnual Meeting of the American Gastroenterological Association, San Diego, Abstract No. 3113 (May 21-24, 2000).
Fasano et al,The Lancet, 355:1518-1519 (2000).
Watts, T. et al., “Role of the intestinal tight junction modulator zonulin in the pathogenesis of type I diabetes in BB diabetic-prone rats,”PNAS(Feb. 22, 2005), vol. 102, No. 8, pp. 2916-2921.

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