Method of use of 8-phenylcyclopentenoquinoline and 8-phenylcyclo

Details Method of use of 8-phenylcyclopentenoquinoline and 8-phenylcyclo Method of use of 8-phenylcyclopentenoquinoline and 8-phenylcyclo

1995-05-25

1996-06-25

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3144

Patent

active

055300057

ABSTRACT:
The use of 8-phenylcyclopentenoquinolines and 8-phenylcyclohexenoquinolines for treating atopic dermatitis, allograft rejection, graft-vs-host disease, and anti-autoimmune disease, and inducing immunosuppression, is disclosed.

REFERENCES:
patent: 4563460 (1986-01-01), Kuhla et al.
Nicholson, et al., Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes, TIPS 12:19-27(1991).
Beavo, et al., Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors, TIPS 11:150-155 (1990).
Livi, et al., Cloning and Expression of cDNA for a Human Low-K.sub.m, Rolipram-Sensitive Cyclic AMP Phosphodiesterase, Mol. Cell. Biol. 10:2678-2686 (1990).
Hirshman, et al., Elevated mononuclear leukocyte phosphodiesterase in allergic dogs with and without airway hyperresponsiveness, J. Allergy Clin. Immunol. 79:46-53 (1987).
Holden et al., Monocyte Locailization of Elevated cAMP Phosphodiesterase Activity in Atopic Dermatitis, J. Invest. Dermatol. 87:372-376 (1986).
Glaser, et al., TVX 2706-a new phosphodiesterase inhibitor with anti-inflammatory action Biochemical characterization, 15:341-348 (1984).
Alvarez, et al., Regulation of Cyclic AMP Metabolism in Human Platelets, Mol. Pharmacol. 20:302-309 (1981).
Thompson, et al., CYCLIC ADENOSINE 3':5'-MONOPHOSPHATE PHOSPHODIESTERASE, J. BIOL. CHEM. 251:4922-4929 (1976).

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