Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1984-06-04
1986-06-17
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549487, 549491, 514229, 549492, 549494, 514231, 549497, 549498, 514233, 549499, 514234, 549500, 514236, 549501, 549502, 514237, 549504, 514239, 514333, 514336, 514422, 514444, 514452, 514464, 514466, 514471, 514473, 544105, 546256, 546281, 546283, 548517, 548518, 549 60, 549362, 549429, 549435, 549472, 549473, 549475, 549483, 549485, 549486, A61K 3134
Patent
active
045956936
ABSTRACT:
Analogs of 2,5-Diaryl tetrahydrofurans which were substituted or unsubstituted at 3,4-positions were prepared.
These compounds are found to have potent and specific PAF (Platelet Activating Factor) antagonistic activities and thereby useful in the treatment of various diseases or disorders mediated by the PAF, for example, inflammation, cardiovascular disorder, asthma, lung edema, adult respiratory distress syndrome, pain, and aggregation of platelets.
REFERENCES:
Biftu et al., J. Chem. Soc., 1147 (1978).
Biftu et al., J. Chem. Soc., 2276 (1979).
Sarkanen et al., J. Chem. Soc. (1973) pp. 1869-1878.
Perry et al., J. Org. Chem., vol. 37 (1972) pp. 4371-4376.
Ahmed et al., Tetrahedron, vol. 32 (1976) pp. 1339-1344.
Beattie Thomas R.
Biftu Tesfaye
Doebber Thomas W.
Hwang San-Bao
Shen Tsung-Ying
Cheng Theresa Y.
Merck & Co. , Inc.
Raymond Richard L.
Sudol Michael C.
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