Method of urinary bladder instillation

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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514 1, 514 25, 514 23, 424422, A61K 31715, A01N 4102

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active

060373326

ABSTRACT:
Growth of transition cell carcinoma cells is found to be inhibited by dextran sulfate. Intravesicular instillation of a dextran sulfate solution prevents growth of bladder carcinoma cells. Dextran sulfate has an inhibitory effect on binding of insulin-like growth factor to bladder tumor cells.

REFERENCES:
patent: 5055301 (1991-10-01), Voight
patent: 5453444 (1995-09-01), Strassman
Whiteley, Toxicologic Pathology 24:681 1996.
Newman, Urology Times, Aug. 1995, p. 15.
Shintani Clin. Exp. Immunol 108:1997.
Imagawa, Gankagakuryoho Jul. 1 (127-131)1980 (Abstract Only).
Oladele J. Urology 153:233A Apr. 1995.
Oladele Proc. Ann. Meet Am. Assoc. Cancer Res., 26:A3590 Mar. 1995.
Kellner, Verh. Dtsch. Ges. Pathol 77:124, 1993 (abstract only).
Coffey, R.J. Jr. et al., "Suramin Inhibition of Growth Factor Receptor Binding and Mitogenicity in AKR-2B Cells," (1987) J. Cellular Physiology 132:143-148.
Gansler, T. et al., "Suramin Inhibits Growth Factor Binding and Proliferation by Urothelial Carcinoma Cell Cultures," (1992) J. Urology 148:910-914.
Graham, S.D. Jr. et al., "Intravesical Suramin in the Prevention of Transitional Cell Carcinoma," (1995) Urology 45(1):59-63.
Pollak, Michael and Richard, Martine, "Suramin Blockade of Insulinlike Growth Factor I-Stimulated Proliferation of Human Osteosarcoma Cells," (1990) J. National Cancer Institute 82(16):1349-1352.
Smith, K. et al., "Characterization and Quantitation of the Epidermal Growth Factor Receptor in Invasive and Superficial Bladder Tumors," (1989) Cancer Reserach 49:5810-5815.
Sorimachi, K. et al., "Inhibition of Fibroblast Growth by Polyanions; Effects of Dextran Sulfate and Lignin Derivatives," (1992) Cell Biology International Reports 16(1)63-71.

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