Method of tumor treatment

Details Method of tumor treatment Method of tumor treatment

1995-05-24

1997-09-23

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514 81, 5142352, 5142342, 514492, A61K 3153, A61K 31535, A61K 31675, A61K 3128

Patent

active

056705026

ABSTRACT:
The present invention provides methods for treating mammalian cancer tumors, preferably solid tumors, comprising administering to a mammal in need of such treatment an effective amount of a 1,2,4-benzotriazine oxide as defined in Formula I or pharmacologically acceptable salts of said compound; and administering to the mammal from about one half hour to about twenty-four hours after administering the 1,2,4-benzotriazine oxide an effective amount of a chemotherapy agent to which the minor is susceptible. The invention also provides kits for treatment of such tumors which comprise a chemotherapy agent and a cytotoxicity-enhancing amount of a 1,2,4-benzotriazine oxide as defined in Formula I.

REFERENCES:
patent: 5175287 (1992-12-01), Lee et al.
Zeman et al., JWT J. Radiation Oncology, Biol Phys., vol. 12, pp. 1239-1242 (1986).
The Merck Index, 11th ED., Merck +Co, Inc, Rahway, N.J., 1989 , p. 1822.

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