Method of tumor regression with VEGF inhibitors

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Structurally-modified antibody – immunoglobulin – or fragment...

Reexamination Certificate

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C424S192100, C514S002600, C514S012200, C530S350000, C536S023400

Reexamination Certificate

active

07354578

ABSTRACT:
Methods of regressing or inhibiting a tumor in a subject by administering an agent capable of blocking, inhibiting, or ameliorating vascular endothelial growth factor (VEGF)-mediated activity to a subject in need thereof such that the tumor is regressed or inhibited. The method of the invention results in a reduction of tumor size and inhibition of tumor metastases. This method is particularly useful for patients suffering from bulky, metastatic cancers.

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patent: 2005/0112061 (2005-05-01), Holash et al.
patent: 2005/0196340 (2005-09-01), Holash et al.
patent: WO00/75319 (2000-12-01), None
Gerber et al. (2000) Cancer Res. 60:6253-6258.
Kim et al. (2002) Proc. Natl. Acad. Sci. USA 99:11399-404.
Holash et al. (2002) Proc. Natl. Acad. Sci. USA 99:11393-8.
Internet Articles, VEGF Trap in Treating Patients With Solid Tumors or Non-Hodgkin's Lymphoma ′Online! XP002305401 Retrieved from the Internet: URL:http://www.clinicaltrials.gov/ct/show/NCT00045266?order=4>.

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