Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1994-08-31
1995-12-12
Prescott, Arthur C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
514120, 514129, 514141, A61K 31665, A61K 3166, A61K 31355
Patent
active
054749921
ABSTRACT:
A pharmaceutical composition for renal disorder and a dialysis solution for extracorporeal hemodialysis which comprise a phosphoric acid diester of the following formula: ##STR1## (wherein R.sub.1 and R.sub.2 are the same or different and each represents a hydrogen atom or a methyl group) or a pharmacologically acceptable salt thereof.
Since the composition of this invention inhibits the formation of free radicals in the body, it can be advantageously used for the prophylaxis and treatment of various renal disorders such as glomerulonephritis, acute renal failure, uremia, adriamycin nephrosis, puromycin nephrosis, gentamicin- and cisplatin-induced disorders of the kidney, renal impairment due to paraquat and other agricultural chemicals, and immune complex nephritis. Moreover, the composition of this invention is also of use as a dialysis solution for extracorporeal hemodialysis with the propylactic/therapeutic effect on dialysis amyloidosis.
REFERENCES:
patent: 4948786 (1990-08-01), Shimamoto et al.
patent: 5306913 (1994-04-01), Suetsugu et al.
Matsuura Sachiko
Nagao Rie
Ogata Kazumi
Ogino Shinya
Saito Noriko
Prescott Arthur C.
Senju Pharmaceutical Co. Ltd.
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