Method of treatment using Tie2 ligand2

Details Method of treatment using Tie2 ligand2 Method of treatment using Tie2 ligand2

2007-12-18

2007-12-18

Mertz, Prema (Department: 1646)

Drug, bio-affecting and body treating compositions

Lymphokine

C514S002600, C514S008100, C514S012200

Reexamination Certificate

active

11073091

ABSTRACT:
The invention provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization, a method of promoting the growth or differentiation of a cell expressing the TIE-2 receptor, a method of blocking the growth or differentiation of a cell expressing the TIE-2 receptor and a method of attenuating or preventing tumor growth in a human.

REFERENCES:
Suri, et al., “Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, During Embryonic Angiogenesis”, Cell 87:1171-1180, 1996.
Maisonpierre, et al., “Angiopoietin-2, a Natural Antagonist for Tie2 that Disrupts In Vivo Angiogenesis”, Science 277:55-60, 1997.
Hackett, et al., “Angiopoietin 2 Expression in the Retina: Upregulation During Physiologic and Pathologic Neovascularization”, Journal of Cellular Physiology 184:275-284, 2000.

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