Method of treatment using an anticoagulant polypeptide

Details Method of treatment using an anticoagulant polypeptide Method of treatment using an anticoagulant polypeptide

1991-05-01

1993-01-12

Lacey, David L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530350, 530395, 435 692, A61K 3702

Patent

active

051790815

ABSTRACT:
A polypeptide having an amino acid sequence as shown in FIG. 1 and its preparation method are disclosed. A DNA fragment capable of coding CPBII polypeptide (human placenta-derived coagulation inhibitor) is first obtained from the human placental cDNA library by using a CPBII-specific antibody as a probe. Then, microorganism cells are transformed by the use of a recombinant plasmid incorporated with the DNA fragment, allowing the resultant transformant to express the CPBII gene, to finally obtain a CPBII-like polypeptide. The polypeptide of this invention exhibits strong anticoagulation activities, and useful for an active component of anticoagulation medicines and preventin in vivo blood coagulation.

REFERENCES:
patent: 4873222 (1989-10-01), Arai
Crompton et al "Primary Structure of the human, membrane-associated Ca.sup.2+ . . . "EMBO v. 7, No. 1 pp. 21-27 Jan. 1988.

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