Method of treatment using 18-cyanoprogesterone derivatives

Details Method of treatment using 18-cyanoprogesterone derivatives Method of treatment using 18-cyanoprogesterone derivatives

1989-01-27

1990-09-04

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

552556, A61K 3157, C07J 900, C07J 500

Patent

active

049544918

ABSTRACT:
The present invention is directed to a method for the treatment of hyperaldosteronism and related disorders which comprises administering to an appropriate patient an appropriate 18-cyanopregnane.

REFERENCES:
patent: 3092627 (1963-06-01), Wettstein et al.
patent: 3684674 (1972-08-01), Anner et al.
Viger et al., J. Steroid Biochemistry, 30, 469, 1988.
J. Steroid Biochemistry, 30, 1988, Cover & Preface.
Kalvoda et al., Helv. Chim. Acta, 49,424(1966).
Kalvoda, Helv. Chim. Acta, 51, 267 (1968).
Kalvoda et al., Helv. Chim. Acta, 52, 2106 (1969).
Kalvoda et al., Helv. Chim. Acta, 55, 356 (1972).
Freerksen et al., J. Am. Chem. Soc., 99, 1536 (1977).
Auel et al., Steroids, 31, 367 (1978).
Holbert et al., Tetrahedron Letters, 26, 1137 (1985).
Viger et al., Tetrahedron, 44, 1127 (1988).
Viger et al., J. Steroid Biochem., 30, 469 (1988).
Chemical Abstracts 74:13344t 1971) (Abstracts of German OLS 2,018,252).
Derwent Abstract 78489R (Abstract of Belgian 749,134; equivalent to U.S. Pat No. 3,684,674).

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