Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-03-07
1995-08-22
Beisner, William H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 16, 514 17, 514 18, 514457, 435 23, 435184, A61K 3700, C12Q 137, C12N 999
Patent
active
054440424
ABSTRACT:
The present invention provides a method of treating a neurodegenerative pathology in a human patient. This method includes selecting a patient for monitoring for the presence of a neurodegenerative pathology associated with enhanced Calpain activity and monitoring the patient for indicia of the onset or existence of such a pathology. In response to the detection of any such indicium of the presence or onset of the pathology, a therapeutically efficacious amount of a Peptide Ketoamide compound, or a pharmaceutically acceptable salt or derivative thereof, together with a pharmaceutically acceptable carrier is administered. The invention also provides additional methods of treatment and pharmaceutical compositions using Peptide Ketoamides, Peptide Ketoacids and Peptide Ketoesters.
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Bartus Raymond T.
Eveleth David D.
Power James C.
Beisner William H.
Cortex Pharmaceuticals
Georgia Tech Research Corporation (GTRC)
Gitomer Ralph
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