Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2005-04-12
2005-04-12
Ungar, Susan (Department: 1642)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
Reexamination Certificate
active
06878688
ABSTRACT:
The present invention relates to a method of treatment of malignant neoplasms and to a complex preparation having antineoplastic activity for use in such treatment. The complex preparation comprises alpha-fetoprotein (AFP), a polyene antibiotic, mainly amphotericin B or nystatin, and a saccharide filler, mainly glucose or dextran 40, dextran 70 and dextran 100, wherein a mass ratio of the AFP to the polyene antibiotic to the saccharide filler is 1:(60-100):(50-70). The method of treatment comprises parenteral injection to a patient in need of such treatment with the said complex preparation in a course of 10 injections once in three days.
REFERENCES:
patent: 2026688 (1995-01-01), None
patent: 2058153 (1996-04-01), None
patent: 2065307 (1996-08-01), None
patent: 2071351 (1997-01-01), None
Gura (Science, 1997, 278:1041-4042).*
Goodman and Gilman, 6th Ed., 1980, MacMillan Publishing Co., NY, p. 861 and p. 1232.*
PubMed abstract PMID:8673023 of Severin, et al., “Alpha-fetoprotein-mediated targeting of anti-cancer drugs to tumor cells in vitro”,Biochem Mol Biol Int. Oct. 1995; 37(2):385-92.
PubMed abstract PMID:10439917 of Severin, et al., “Antitumor activity of a covalent conjugate of the endiene antibiotic esperamicin A1 with human alpha-fetoprotein”,Dokl Akad Nauk. Jun. 1999; 366(4):561-4.
Russian Agency for Patents and Trademarks abstracts of RU 2 1 34589 published Aug. 20, 1999, “Method of Treatment of Patients with Primary Liver Cancer and Set for Treatment of Patients with Primary Liver Cancer”.
Russian Agency for Patents and Trademarks abstract of RU 2179452 published Feb. 20, 2002, “Method to Treat Malignant Neoplasms and Combined Preparation of Antitumor Action to Perform the Method”.
Nikonov Sergei Danilovich
Ogirenko Anatoli Pavlovich
Pak Natalia Anatolievna
Pak Vladimir Nikolaevich
Reshetnikov Sergei Stepanovich
Celecure AS
Ladas & Parry LLP
Ungar Susan
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